CM 11

Names

[ CAS No. ]:
2244684-49-7

[ Name ]:
CM 11

Biological Activity

[Description]:

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

pVHL30[1] PROTAC[1]

[In Vitro]

Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].

[References]

[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₈H₈₂N₈O₁₄S₂

[ Molecular Weight ]:
1179.45

[ Storage condition ]:
2-8℃

CM 11

Names

Biological Activity

Chemical & Physical Properties

Related Compounds