JNc-440

Names

[ CAS No. ]:
1119503-63-7

[ Name ]:
JNc-440

[Synonym ]:
2-Quinazolinecarboxamide, N-[3-[(2,2-diphenylacetyl)amino]propyl]-4-hydroxy-
N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide

Biological Activity

[Description]:

JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3; shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice.

[References]

References 1. He D, et al. EMBO Mol Med. 2017 Sep 12. pii: e201707725. View Related Products by Target TRP Channel

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₆H₂₄N₄O₃

[ Molecular Weight ]:
440.494

[ Exact Mass ]:
440.184845

[ LogP ]:
2.23

[ Index of Refraction ]:
1.656

Related Compounds

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