3-Methyladenine-d3

Names

[ CAS No. ]:
110953-39-4

[ Name ]:
3-Methyladenine-d3

[Synonym ]:
3-(Methyl-d3)-6-aminopurine
N3-(Methyl-d3)adenine
3-Methyl Adenine-d3
3-Methyl-d3-adenine
6-Amino-3-(methyl-d3)purine
3-(Methyl-d3)-3H-purin-6-amine

Biological Activity

[Description]:

3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Autophagy >> Mitophagy

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7.  

[3]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 20127(4):e35665.  

[4]. Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 20162016:8369704.  

Chemical & Physical Properties

[ Molecular Formula ]:
C6H4D3N5

[ Molecular Weight ]:
152.17200

[ Exact Mass ]:
152.08900

[ PSA ]:
69.62000

[ LogP ]:
0.52670

Related Compounds