Neocryptotanshinone

Names

[ Name ]:
Neocryptotanshinone

[Synonym ]:
1-hydroxy-2-(1-hydroxypropan-2-yl)-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
Neocryptotanshinone
1,4-Phenanthrenedione,5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl

Biological Activity

[Description]:

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

[References]

[1]. Chuanhong Wu, et al. Neocryptotanshinone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppression of NF-κB and iNOS Signaling Pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9.

[2]. H C Lin, et al. Two New Fatty Diterpenoids From Salvia Miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50.

Chemical & Physical Properties

[ Density]:
1.255g/cm3

[ Boiling Point ]:
505.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₂O₄

[ Molecular Weight ]:
314.37600

[ Flash Point ]:
273.5ºC

[ Exact Mass ]:
314.15200

[ PSA ]:
74.60000

[ LogP ]:
2.96340

[ Vapour Pressure ]:
4.93E-11mmHg at 25°C

[ Index of Refraction ]:
1.602

[ Water Solubility ]:
Insuluble (2.8E-3 g/L) (25 ºC)

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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