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TC-S 7005

Names

[ CAS No. ]:
1082739-92-1

[ Name ]:
TC-S 7005

Biological Activity

[Description]:

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK)

[Target]

PLK2:4 nM (IC50)

PLK3:24 nM (IC50)

PLK1:214 nM (IC50)


[References]

[1]. Hanan EJ, et al. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5186-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H17N3O3

[ Molecular Weight ]:
359.38

[ Storage condition ]:
-20°C

Related Compounds