Loperamide
Names
[ CAS No. ]:
106900-12-3
[ Name ]:
Loperamide
[Synonym ]:
Loperamide N-oxide
Loperamide oxide
trans-N-Oxide of loperamide
Arestal
Chemical & Physical Properties
[ Molecular Formula ]:
C29H33ClN2O3
[ Molecular Weight ]:
493.03700
[ Exact Mass ]:
492.21800
[ PSA ]:
69.97000
[ LogP ]:
5.05940
[ Water Solubility ]:
Practically insoluble in water, freely soluble in alcohol and in methylene chloride.
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM4960200
- CHEMICAL NAME :
- 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha -diphenyl-, 1-oxide, (E)-
- CAS REGISTRY NUMBER :
- 106900-12-3
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C29-H33-Cl-N2-O3
- MOLECULAR WEIGHT :
- 493.09
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 172 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986
Safety Information
[ RIDADR ]:
UN 2811 6.1 / PGIII
[ RTECS ]:
TM4960200