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AL 8697

Names

[ CAS No. ]:
1057394-06-5

[ Name ]:
AL 8697

[Synonym ]:
al 8697

Biological Activity

[Description]:

AL 8697 is a selective p38 MAPK inhibitor with IC50s of 6 nM and 82 nM for p38α and p38β, respectively[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Inflammation/Immunology

[Target]

p38α:6 nM (IC50)

p38β:82 nM ()


[References]

[1]. Balagué C, et al. Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br J Pharmacol. 2012 Jun;166(4):1320-32.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H21F3N4O

[ Molecular Weight ]:
402.41

[ Exact Mass ]:
402.16700

[ PSA ]:
59.29000

[ LogP ]:
4.70260

Related Compounds