1057394-06-5

1057394-06-5 structure

Name: AL 8697
Chemical Name: 3-(3-tert-butyl-6,8-difluoro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide
CAS Number: 1057394-06-5
Molecular Formula: C₂₁H₂₁F₃N₄O
Molecular Weight: 402.41
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2018-06-02 00:44:26
Modify Date: 2025-09-18 18:46:34
AL 8697 is a selective p38 MAPK inhibitor with IC50s of 6 nM and 82 nM for p38α and p38β, respectively[1].

Name	3-(3-tert-butyl-6,8-difluoro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide
Synonyms	al 8697

Description	AL 8697 is a selective p38 MAPK inhibitor with IC50s of 6 nM and 82 nM for p38α and p38β, respectively[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
Target	p38α:6 nM (IC50) p38β:82 nM ()
References	[1]. Balagué C, et al. Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br J Pharmacol. 2012 Jun;166(4):1320-32.