MK-4074 sodium salt
Names
[ CAS No. ]:
1039758-18-3
[ Name ]:
MK-4074 sodium salt
Biological Activity
[Description]:
MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver. Steatohepatitis Phase 1 Clinical
[References]
References 1. Kim CW, et al. Cell Metab. 2017 Aug 1;26(2):394-406.e6. View Related Products by Target Acetyl-CoA Carboxylase (ACC) Steatohepatitis
Chemical & Physical Properties
[ Molecular Formula ]:
C33H30N3NaO6
[ Molecular Weight ]:
587.608