D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt

Names

[ Name ]:
D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt

[Synonym ]:
1,2,3,4,5,6-Cyclohexanehexol, 1,2,4-tris(dihydrogen phosphate), potassium salt, (1R,2R,3S,4R,5R,6S)- (1:6)
1D-myo-inositol 1,3,4-triphosphate hexapotassium salt
2,4-bis[(dipotassiooxyphosphoryl)oxy]-3,5,6-trihydroxycyclohexyl dipotassium phosphate
D-myo-INOSITOL-1,4,5-TRISPHOSPHATE (POTASSIUM SALT)
Hexapotassium (1R,2R,3S,4R,5R,6S)-3,5,6-trihydroxy-1,2,4-cyclohexanetriyl tris(phosphate)
MFCD00077799
Hexapotassium (1R,2R,3S,4R,5R,6S)-3,5,6-trihydroxycyclohexane-1,2,4-triyl tris(phosphate)
D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt
D-MYO-INOSITOL

Biological Activity

[Description]:

D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is the hexapotassium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

Second messenger D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3) is served as an inositol phosphate derivative. The dissociation constant (KD) for Pr55Gag complexed with D-myo-Inositol 1,4,5-trisphosphate (an inositol with divalent phosphate groups and devoid of lipid groups) is 2170 μM. The binding affinities of D-myo-Inositol 1,4,5-trisphosphate (KD=568 μM) and 1,3,4,5-IP4 (KD=526 μM) for matrix (MA) are almost identical[1].

[References]

[1]. Anraku K, et al. Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance. Biochemistry. 2010 Jun 29;49(25):5109-16.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₉K₆O₁₅P₃

[ Molecular Weight ]:
648.638

[ Exact Mass ]:
647.697693

[ PSA ]:
307.38000

[ Storage condition ]:
−20°C

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26

[ WGK Germany ]:
3

Related Compounds

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