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LY2452473

Names

[ CAS No. ]:
1029692-15-6

[ Name ]:
LY2452473

[Synonym ]:
unii-xkw9myf94y
LY2452473

Biological Activity

[Description]:

LY2452473 is an orally bioavailable, selective androgen receptor modulator (SARM).

[Related Catalog]:

Signaling Pathways >> Others >> Androgen Receptor
Research Areas >> Cancer
Research Areas >> Metabolic Disease

[Target]

Androgen receptor[1]


[In Vivo]

LY2452473 is a selective androgen receptor modulator being developed for the treatment of disorders related to hypogonadism. LY2452473 is absorbed rapidly (time to reach maximum plasma concentration for both LY2452473 and total radioactivity is 2-3 h) and cleared slowly (plasma terminal t1/2 of 27 h for LY2452473 and 51 h for the total radioactivity)[1].

[References]

[1]. Yi P, et al. Disposition and metabolism of LY2452473, a selective androgen receptor modulator, in humans. Drug Metab Dispos. 2012 Dec;40(12):2354-64.


[Related Small Molecules]

ARN-509 | Dehydroepiandrosterone | Flutamide | ODM-201 | Danazol | 3,3'-Diindolylmethane | AZD3514 | RAD140 | BMS-564929 | GLPG0492 | Cyproterone acetate | LGD-4033 | Lupeol | Andarine | MK-0773

Chemical & Physical Properties

[ Molecular Formula ]:
C22H22N4O2

[ Molecular Weight ]:
374.43600

[ Exact Mass ]:
374.17400

[ PSA ]:
83.43000

[ LogP ]:
3.76248

[ Storage condition ]:
2-8℃

Related Compounds

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