4,4'-Methylenebis(N,N-dimethylaniline)
Names
[ CAS No. ]:
101-61-1
[ Name ]:
4,4'-Methylenebis(N,N-dimethylaniline)
[Synonym ]:
N,N,N',N'-tetramethyl-4,4'-diaminodiphenylmethane
TETRA BASE
ARNOLDS BASE
4,4-METHYLENEBIS(N,N-DIMETHYLANILINE)
4,4'-BIS-(DIMETHYLAMINO)DIPHENYLMETHANE
methylenebase
4,4'-Tetramethyldiaminodiphenylmethane
4,4'- Methylenebis-(n,n-dimethylaniline)
4,4‘-Methylenebis(N,N-dimethylaniline)
METHANE BASE
4,4-METHYLENE-BISDIMETHYLANILINE
4,4'-METHYLENEBIS(N,N'-DIMETHYLANILINE)
4,4'-METHYLENEBIS
4,4'-BIS(DIMETHYLAMINO)-DIPHENYLMETHANE
Bis-(4-dimethylaminophenyl)methane
4,4-BIS(DIMETHYLAMINO)DIPHENYLMETHANE
Bis[4-(dimethylamino)phenyl]methane
N,N,N',N'-tetramethyl-4,4'-methylenedianiline
4,4'-METHANEDIYLBIS(N,N-DIMETHYLANILINE)
4,4'-BIS(DIMETHYLAMINO)DIPHENYL METHANE
Michler's hydride
4,4-METHYLENEBIS(N,N'-DIMETHYLANILINE)
4,4'-BIS(DIMETHYLAMINO)DIPHENYLMETHANE
MFCD00008317
4,4 -METHYLENEBIS(N,N-DIMETHYLANILINE)
BENZENAMINE,4,4'-METHYLENEBIS[N,N-DIMETHYL-
EINECS 202-959-2
4,4'-METHYLENE-BIS-(N,N-DIMETHYLANILINE)
Michler's base
BIS-(4-DIMETHYLAMINOPHENYL)-METHAN
bazemichlerova
Chemical & Physical Properties
[ Boiling Point ]:
390 °C
[ Melting Point ]:
88-89 °C(lit.)
[ Molecular Formula ]:
C17H22N2
[ Molecular Weight ]:
254.37000
[ Flash Point ]:
178 °C
[ Exact Mass ]:
254.17800
[ PSA ]:
6.48000
[ LogP ]:
3.40940
[ Vapour Pressure ]:
5.15E-08mmHg at 25°C
[ Index of Refraction ]:
1.615
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
Insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BY5250000
- CHEMICAL NAME :
- Aniline, 4,4'-methylenebis(N,N-dimethyl-
- CAS REGISTRY NUMBER :
- 101-61-1
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 40
- MOLECULAR FORMULA :
- C17-H22-N2
- MOLECULAR WEIGHT :
- 254.41
- WISWESSER LINE NOTATION :
- 1N1&R D1R DN1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8500 mg/kg/59W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 82 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 164 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 310 gm/kg/59W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 155 gm/kg/59W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 683 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1365 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15488 mg/kg/59W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7744 mg/kg/59W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - rabbit Lymphocyte
- DOSE/DURATION :
- 50 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,197,1981 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,119,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,119,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.8 mg/m3);STEL 0.5 ppm JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3405 No. of Facilities: 53 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 1563 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3405 No. of Facilities: 631 (estimated) No. of Industries: 15 No. of Occupations: 9 No. of Employees: 4140 (estimated)
Safety Information
[ Symbol ]:
GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H350-H410
[ Precautionary Statements ]:
P201-P273-P308 + P313-P501
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R45;R50/53
[ Safety Phrases ]:
S53-S45-S60-S61
[ RIDADR ]:
UN 3077 9/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
BY5250000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
29215990
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921590090
[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Cancer Res. 42(9) , 3475-9, (1982)
Studies on the in vivo and in vitro disposition of 4,4'-[14C]-methylenebis(N,N-dimethyl)benzamine (reduced Michler's ketone, RMK) were performed. Osborne-Mendel rats retained, after 24 hr, 78% of a p....
4,4'-Methylenebis(N,N-dimethyl)benzenamine.IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 27 , 119-26, (1982)
[Antiarrhythmic effects of bis(dimethyl amino)-diphenyl methane (BDDM)].
Yao Xue Xue Bao 23(6) , 448-51, (1988)