Ipatasertib-NH2 dihydrochloride

Names

[ Name ]:
Ipatasertib-NH2 dihydrochloride

Biological Activity

[Description]:

Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₈Cl₃N₅O₂

[ Molecular Weight ]:
488.84

[ Storage condition ]:
2-8°C

Related Compounds

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