环孢菌素

• 常用名: 环孢菌素
• 英文名: Cyclosporine
• CAS号: 79217-60-0
• 分子量: 1202.611
• 密度: 1.0±0.1 g/cm3
• 沸点: 1293.8±65.0 °C at 760 mmHg
• 分子式: C₆₂H₁₁₁N₁₁O₁₂
• 熔点: 148-151ºC
• 闪点: 736.3±34.3 °C

环孢菌素用途

环孢菌素是一种环状十肽,可从土壤真菌充气菌Tolypocladium inflatum中分离出来。环孢霉素是一种免疫抑制剂,被认为与T淋巴细胞中的亲环蛋白结合[1]。

环孢菌素名称

• 中文名: 环孢菌素
• 英文名: Cyclosporine
• 中文别名: 赛斯平 | 环孢霉素A

环孢菌素生物活性

• 描述: 环孢菌素是一种环状十肽,可从土壤真菌充气菌Tolypocladium inflatum中分离出来。环孢霉素是一种免疫抑制剂,被认为与T淋巴细胞中的亲环蛋白结合[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 环孢菌素(0-2500 nM；Ppia-/-细胞) 以相似的程度抑制 Ppia+/+或 < i> Ppia+/-脾细胞增值,国际50值为 25 nM,Ppia-/-脾细胞的 国际50值至少高出 10倍[1]。 环孢菌素 (0-750 nM；Ppia-/-细胞) 抑制 Ppia-/-细胞中的基因表达[1]。
• 参考文献:

  [1]. Colgan J, et, al. Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. J Immunol. 2005 May 15;174(10):6030-8.

环孢菌素物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 1293.8±65.0 °C at 760 mmHg
• 熔点: 148-151ºC
• 分子式: C₆₂H₁₁₁N₁₁O₁₂
• 分子量: 1202.611
• 闪点: 736.3±34.3 °C
• 精确质量: 1201.841309
• PSA: 292.76000
• LogP: 3.35
• 外观性状: 白色结晶性粉末
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.468
• 储存条件: -20°C

环孢菌素毒性和生态

环孢菌素安全信息

• 危害码 (欧洲): T, Xn
• 风险声明 (欧洲): 45-60-22-40
• 安全声明 (欧洲): 53-45-36/37-24/25-22

环孢菌素英文别名

• cyclosporine
• 30-Ethyl-33-[(4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• Cyclosporin
• 30-Ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• Sandimmune
• S1514_Selleck
• 30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• Gengraf
• 30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• Neoral
• 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 30-ethyl-33-[(4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-
• 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• MFCD01771104