抗螺旋體鏈絲菌素

更新时间：2024-01-02 20:36:55

抗螺旋體鏈絲菌素结构式	常用名	抗螺旋體鏈絲菌素	英文名	(-)-borrelidin
	CAS号	7184-60-3	分子量	489.644
	密度	1.1±0.1 g/cm3	沸点	710.3±60.0 °C at 760 mmHg
	分子式	C₂₈H₄₃NO₆	熔点	143-145℃
	MSDS	中文版美版	闪点	383.4±32.9 °C

抗螺旋體鏈絲菌素用途

Borrelidin (Treponemycin) 是从 Streptomyces rochei 中分离的一种含氮大环内酯类抗生素,能作为抑制细菌和真核 threonyl-tRNA 合成酶的抑制剂,通过诱导细胞凋亡和介导 G1 期阻滞作用来靶向 ALL 细胞。Borrelidin (Treponemycin) 是一种出芽酵母细胞周期蛋白依赖性激酶 (CDK) Cdc28/Cln2 的抑制剂,其 IC50 值为 24 μM。Borrelidin (Treponemycin) 是一种强效的血管生成抑制剂,其 IC50 值为 0.8 nM,可诱导血管形成细胞凋亡。Borrelidin (Treponemycin) 具有较强的抗疟活性,对恶性疟原虫 K1 株和 FCR3 株作用的 IC50 值分别为 1.9 nM 和 1.8 nM。

中文名	抗螺旋体链丝菌素
英文名	borrelidin
中文别名	疏螺体素 \| 疏螺旋体素 \| 抗螺旋體鏈絲菌素
英文别名	更多

描述	Borrelidin (Treponemycin) 是从 Streptomyces rochei 中分离的一种含氮大环内酯类抗生素,能作为抑制细菌和真核 threonyl-tRNA 合成酶的抑制剂,通过诱导细胞凋亡和介导 G1 期阻滞作用来靶向 ALL 细胞。Borrelidin (Treponemycin) 是一种出芽酵母细胞周期蛋白依赖性激酶 (CDK) Cdc28/Cln2 的抑制剂,其 IC50 值为 24 μM。Borrelidin (Treponemycin) 是一种强效的血管生成抑制剂,其 IC50 值为 0.8 nM,可诱导血管形成细胞凋亡。Borrelidin (Treponemycin) 具有较强的抗疟活性,对恶性疟原虫 K1 株和 FCR3 株作用的 IC50 值分别为 1.9 nM 和 1.8 nM。
相关类别	信号通路 >> 抗感染 >> 寄生物信号通路 >> 细胞凋亡 >> 细胞凋亡研究领域 >> 感染信号通路 >> 细胞周期/DNA损伤 >> CDK
靶点	IC50：24μM (Cdc28/Cln2)[2]
参考文献	[1]. Habibi D, et al. Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia. Invest New Drugs. 2012 Aug;30(4):1361-70. [2]. Tsuchiya E, et al. Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae. J Antibiot (Tokyo). 2001 Jan;54(1):84-90. [3]. Wakabayashi T, et al. Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. J Antibiot (Tokyo). 1997 Aug;50(8):671-6. [4]. Otoguro K, et al. In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. J Antibiot (Tokyo). 2003 Aug;56(8):727-9.

密度	1.1±0.1 g/cm3
沸点	710.3±60.0 °C at 760 mmHg
熔点	143-145℃
分子式	C₂₈H₄₃NO₆
分子量	489.644
闪点	383.4±32.9 °C
精确质量	489.309052
PSA	127.85000
LogP	4.31
外观性状	白色至灰白色粉末
蒸汽压	0.0±5.1 mmHg at 25°C
折射率	1.539
储存条件	库房通风低温干燥,与食品原料分开存放
水溶解性	DMSO: 1 mg/mL

抗螺旋體鏈絲菌素毒性英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	T+
安全声明 (欧洲)	24/25
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	ED8750000
海关编码	29419090

Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studies.

Antimicrob. Agents Chemother. 55(4) , 1784-6, (2011)

We further examined the usefulness of previously reported Bacillus subtilis biosensors for antibacterial mode-of-action studies. The biosensors could not detect the tRNA synthetase inhibitors mupiroci...

Total synthesis of borrelidin.

J. Org. Chem. 72 , 2744, (2007)

The total synthesis of borrelidin has been achieved. The best feature of our synthetic route is macrocyclization at C11-C12 for the construction of an 18-membered ring after esterification between two...

Iterative deoxypropionate synthesis based on a copper-mediated directed allylic substitution: formal total synthesis of borrelidin (C3-C11 fragment).

Chemistry 12(25) , 6684-91, (2006)

A new iterative strategy for the flexible preparation of any oligodeoxypropionate stereoisomer is presented which relies on an o-DPPB-directed copper mediated allylic substitution employing enantiomer...

Borrelidin

Cyclopentanecarboxylic acid, 2-[(2S,4Z,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]-, (1R,2R)-

Borrelidine

Quinquangulin K 031

2-(7-CYANO-8,16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18-OXOOXACYCLOOCTADECA-4,6-DIEN-2-YL)-CYCLOPENTANECARBOXYLIC ACID

Quinquangulin K 182

Cyclopentanecarboxylic acid, 2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]-, (1R,2R)-

(1R,2R)-2-[(2S,4Z,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid

(1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid

(-)-borrelidine

TREPONEMYCIN