106291-80-9

• 常用中文名：4-溴-3-羟基苯甲酸甲酯
• 常用英文名：Methyl 4-bromo-3-hydroxybenzoate
• CAS号：106291-80-9
• 分子式：C₈H₇BrO₃
• 分子量：231.043
• 相关类别： 化学试剂 有机试剂 芳烃
• 发布时间：2018-06-08 14:13:52
• 更新时间：2024-01-01 19:00:02

名称

• 中文名: 4-溴-3-羟基苯甲酸甲酯
• 英文名: Methyl 4-bromo-3-hydroxybenzoate
• 中文别名: 3-羟基-4-溴苯甲酸甲酯
• 英文别名: 4-Bromo-3-hydroxy-benzoic acid ; methyl ester; Benzoic acid, 4-bromo-3-hydroxy-, methyl ester; 4-Bromo-3-hydroxybenzoic Acid Methyl Ester; Methyl 4-bromo-3-hydroxybenzoate

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 318.0±22.0 °C at 760 mmHg
• 熔点: 121-125ºC
• 分子式: C₈H₇BrO₃
• 分子量: 231.043
• 闪点: 146.1±22.3 °C
• 精确质量: 229.957855
• PSA: 46.53000
• LogP: 2.86
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.585
• 储存条件: Keep Cold

MSDS

Methyl 4-Bromo-3-hydroxybenzoate Revision number: 5 SAFETY DATA SHEET Section1. IDENTIFICATION Product name:Methyl 4-Bromo-3-hydroxybenzoate Revision number:5 Section2. HAZARDS IDENTIFICATION GHS classification PHYSICAL HAZARDSNot classified HEALTH HAZARDS Skin corrosion/irritationCategory 2 Category 2A Serious eye damage/eye irritation ENVIRONMENTAL HAZARDSNot classified GHS label elements, including precautionary statements Pictograms or hazard symbols Signal wordWarning Hazard statementsCauses skin irritation Causes serious eye irritation Precautionary statements: Wash hands thoroughly after handling. [Prevention] Wear protective gloves/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, [Response] if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. IF ON SKIN: Gently wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance/mixture:Substance Components:Methyl 4-Bromo-3-hydroxybenzoate Percent:>98.0%(GC) CAS Number:106291-80-9 Synonyms:4-Bromo-3-hydroxybenzoic Acid Methyl Ester C8H7BrO3 Chemical Formula: Section4. FIRST AID MEASURES Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. Methyl 4-Bromo-3-hydroxybenzoate Section4. FIRST AID MEASURES Skin contact:Remove/Take off immediately all contaminated clothing. Gently wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention. Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Ingestion:Get medical advice/attention if you feel unwell. Rinse mouth. A rescuer should wear personal protective equipment, such as rubber gloves and air- Protection of first-aiders: tight goggles. Section5. FIRE-FIGHTING MEASURES Suitable extinguishingDry chemical, foam, water spray, carbon dioxide. media: Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to from the chemical:generate poisonous fume. Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so. Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Personal precautions,Use personal protective equipment. Keep people away from and upwind of spill/leak. protective equipment and Entry to non-involved personnel should be controlled around the leakage area by emergency procedures: roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it. containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with up: appropriate laws and regulations. Section7. HANDLING AND STORAGE Precautions for safe handling Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment. Prevent dispersion of dust. Wash hands and face thoroughly after handling. Use a local exhaust if dust or aerosol will be generated. Advice on safe handling: Avoid contact with skin, eyes and clothing. Conditions for safe storage, including any incompatibilities Storage conditions:Keep container tightly closed. Store in a cool and dark place. Store under inert gas. Store away from incompatible materials such as oxidizing agents. Air-sensitive Packaging material:Comply with laws. Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering controls:Install a closed system or local exhaust as possible so that workers should not be exposed directly. Also install safety shower and eye bath. Personal protective equipment Respiratory protection: Dust respirator. Follow local and national regulations. Hand protection:Protective gloves. Safety glasses. A face-shield, if the situation requires. Eye protection: Skin and body protection: Protective clothing. Protective boots, if the situation requires. Section9. PHYSICAL AND CHEMICAL PROPERTIES Physical state (20°C):Solid Crystal- Powder Form: Methyl 4-Bromo-3-hydroxybenzoate Section9. PHYSICAL AND CHEMICAL PROPERTIES Colour:White - Very pale yellow Odour:No data available pH: No data available Melting point/freezing point:123°C Boiling point/range:No data available Flash point:No data available Flammability or explosive limits: Lower:No data available Upper:No data available Relative density:No data available Solubility(ies): [Water]No data available [Other solvents] Soluble:Methanol Section10. STABILITY AND REACTIVITY Chemical stability:Stable under proper conditions. Possibility of hazardous No special reactivity has been reported. reactions: Incompatible materials: Oxidizing agents Hazardous decomposition Carbon monoxide, Carbon dioxide, Hydrogen bromide products: Section11. TOXICOLOGICAL INFORMATION Acute Toxicity:No data available Skin corrosion/irritation: No data available Serious eyeNo data available damage/irritation: Germ cell mutagenicity: No data available Carcinogenicity: IARC =No data available NTP =No data available Reproductive toxicity:No data available Section12. ECOLOGICAL INFORMATION Ecotoxicity: No data available Fish: Crustacea:No data available No data available Algae: Persistence / degradability: No data available No data available Bioaccumulative potential(BCF): Mobility in soil Log Pow:No data available No data available Soil adsorption (Koc): Henry's LawNo data available constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section14. TRANSPORT INFORMATION Hazards Class:Does not correspond to the classification standard of the United Nations Methyl 4-Bromo-3-hydroxybenzoate Section14. TRANSPORT INFORMATION UN-No:Not listed Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002 and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 海关编码: 2918290000

合成路线

67-56-1 14348-38-0 ~95% 106291-80-9

文献：Burrows, Andrew D.; Hunter, Sally O.; Mahon, Mary F.; Richardson, Christopher Chemical Communications, 2013 , vol. 49, # 10 p. 990 - 992

63435-16-5 ~% 106291-80-9

文献：US2004/97485 A1, ; Page/Page column 35 ; US 20040097485 A1

14348-38-0 ~% 106291-80-9

文献：US2002/198195 A1, ;

19438-10-9 ~48% 106291-80-9

文献：Hinsberger, Stefan; Huesecken, Kristina; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W. Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8332 - 8338

99-06-9 ~% 106291-80-9

文献：Journal of Medicinal Chemistry, , vol. 50, # 15 p. 3540 - 3560

上下游产品

上游产品  5
67-56-1 14348-38-0 63435-16-5 19438-10-9
99-06-9
下游产品  5
1065074-12-5 56256-14-5 1261933-36-1 17100-63-9
473264-21-0

海关

海关编码	2918290000
中文概述	2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%