5868-05-3

• 常用中文名：烟酸戊四醇酯
• 常用英文名：Niceritrol
• CAS号：5868-05-3
• 分子式：C₂₉H₂₄N₄O₈
• 分子量：556.523
• 相关类别： 研究领域 其他
• 发布时间：2016-05-21 05:15:42
• 更新时间：2024-01-11 14:02:47
• 尼塞特罗是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

名称

• 中文名: 烟酸戊四醇酯
• 英文名: [3-(pyridine-3-carbonyloxy)-2,2-bis(pyridine-3-carbonyloxymethyl)propyl] pyridine-3-carboxylate
• 英文别名: 3-[(3-Pyridinylcarbonyl)oxy]-2,2-bis{[(3-pyridinylcarbonyl)oxy]methyl}propyl nicotinate; Cardiolipol; 3-Pyridinecarboxylic Acid 2,2-Bis-[[(3-pyridinylcarbonyl)oxy]methyl]-1,3-propanediyl Ester; 3-[(pyridin-3-ylcarbonyl)oxy]-2,2-bis{[(pyridin-3-ylcarbonyl)oxy]methyl}propyl pyridine-3-carboxylate; 8 AL; Niceritrol; Pentaerithritol tetranicotinate; Bufor; tetrakis(nicotinoxymethyl)methane; 3-pyridinecarboxylic acid 2,2-bis[[(3-pyridinylcarbonyl)oxy]methyl]-1,3-propanediyl ester; 1,3-Bis-nicotinoyloxy-2,2-bis-nicotinoyloxymethyl-propan; Niceritrolum [INN-Latin]; Perycit; Pentaerythritol tetranicotinate; SK 1 (Pharmaceutical); 3-pyridinecarboxylic acid, 3-[(3-pyridinylcarbonyl)oxy]-2,2-bis[[(3-pyridinylcarbonyl)oxy]methyl]propyl ester; pentaerythrityl tetranicotinate; Niceritrol [INN:BAN:DCF:JAN]; Nicotinic Acid Neopentanetetrayl Ester; 1,3-bis-nicotinoyloxy-2,2-bis-nicotinoyloxymethyl-propane

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 746.7±60.0 °C at 760 mmHg
• 熔点: 162-166°C
• 分子式: C₂₉H₂₄N₄O₈
• 分子量: 556.523
• 闪点: 405.4±32.9 °C
• 精确质量: 556.159424
• PSA: 156.76000
• LogP: 4.62
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.608
• 储存条件: 室温

生物活性

• 描述: 尼塞特罗是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。
• 相关类别:
  研究领域 >> 其他

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QT1980000 CHEMICAL NAME : Nicotinic acid, neopentanetetrayl ester CAS REGISTRY NUMBER : 5868-05-3 BEILSTEIN REFERENCE NO. : 0377170 LAST UPDATED : 199706 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C29-H24-N4-O8 MOLECULAR WEIGHT : 556.57 WISWESSER LINE NOTATION : T6NJ CVO1X1OV- CT6NJ&1OV- CT6NJ&1OV- CT6NJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >20 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >20 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 72 gm/kg/5W-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,829,1977

合成路线

115-77-5 20260-53-1 ~94% 5868-05-3

文献：Grosshans, Philippe; Jouaiti, Abdelaziz; Hosseini, Mir Wais; Kyritsakas, Nathalie New Journal of Chemistry, 2003 , vol. 27, # 5 p. 793 - 797