146665-77-2

• 常用中文名：依铂(SKI-2053R)
• 常用英文名：sunpla
• CAS号：146665-77-2
• 分子式：C₁₁H₂₀N₂O₆Pt
• 分子量：471.36
• 相关类别： 研究领域 癌症
• 发布时间：2018-04-21 08:00:00
• 更新时间：2024-01-07 20:21:02
• 七铂(SKI 2053R)是一种铂衍生物,对多种癌细胞系具有抗癌活性,包括对顺铂耐药的肿瘤细胞系。SKI-2053R在胃腺癌的研究中非常活跃,具有良好的毒性特征[1]。

名称

• 中文名: 依铂
• 英文名: Eptaplatin
• 中文别名: 庚铂; 舒铂; [SP-4-2-[4R-(2a,4a,5b)]]-[2-异丙基-1,3-二氧五环-4,5-二甲胺-N,N'][丙二酸(2-)-O,O']-铂
• 英文别名: [propanedioato(2-)-κO,O]platinum - [(4R,5R)-2-(propan-2-yl)-1,3-dioxolane-4,5-diyl]dimethanamine (1:1); (SP-4-2)-[(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5; Platinum(2+) malonate [(4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl]dimethanamine (1:1:1); platinum, [propanedioato(2-)-κO,κO]-, compd. with (4R,5R)-2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine (1:1); EPTAPLATIN,SUNPLA; SKI 2053R; [Malonato(2-)-κO,O]platinum - [(4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl]dimethanamine (1:1); sunpla; EPOXYPROGESTERONE; Heptaplatin; cis-[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](malonate)platinum(II); (SP-4-2)-[(4R,5R)-2-ISOPROPYL-1,3-DIOXOLANE-4,5-BIS(METHANAMINE)-N,N'][PROPANEDIOATO(2-)-O,O']PLATINUM

物化性质

• 沸点: 261.5ºC at 760 mmHg
• 熔点: 43-49ºC
• 分子式: C₁₁H₂₀N₂O₆Pt
• 分子量: 471.36
• 闪点: 114ºC
• 精确质量: 471.096924
• PSA: 123.10000
• LogP: 0.45950
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0115mmHg at 25°C
• 储存条件: 2-8°C，避光，惰性气体保存

生物活性

• 描述: 七铂(SKI 2053R)是一种铂衍生物,对多种癌细胞系具有抗癌活性,包括对顺铂耐药的肿瘤细胞系。SKI-2053R在胃腺癌的研究中非常活跃,具有良好的毒性特征[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Kim NK, et al. Phase II clinical trial of SKI-2053R, a new platinum analog, in the treatment of patients with advanced gastric adenocarcinoma. Cancer. 1999;86(7):1109-1115.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TP2505900 CHEMICAL NAME : Platinum, (2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-N, N')(propanedioato(2-) -O,O')-, (SP-4-2-(4R-(2-alpha,4-alpha,5-beta)))- CAS REGISTRY NUMBER : 146665-77-2 LAST UPDATED : 199509 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C11-H20-N2-O6-Pt MOLECULAR WEIGHT : 471.42 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 182 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1590 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 198 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 235 mg/kg/13W-I TOXIC EFFECTS : Blood - normocytic anemia Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,217,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 15 mg/kg/90D-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death REFERENCE : KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,235,1992

安全

• 危害码 (欧洲): Xn