501-75-7

• 常用中文名：2-(1-甲基-1H-咪唑-4-基)乙-1-胺
• 常用英文名：Nτ-methylhistamine
• CAS号：501-75-7
• 分子式：C₆H₁₁N₃
• 分子量：125.17
• 相关类别： 研究领域 其他
• 发布时间：2018-11-28 16:06:07
• 更新时间：2024-01-12 23:22:24
• 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine 是一种组胺 (Him) 代谢物。

名称

• 中文名: 2-(1-甲基-1H-咪唑-4-基)乙胺
• 英文名: Nτ-methylhistamine
• 中文别名: 2-(1-甲基咪唑-4-基)乙胺
• 英文别名: N-Methylhistamine; N1-Methylhistamine; N-Telle-methylhistamine; 1-Methylhistamine; 2-(1-methylimidazol-4-yl)ethanamine; N(tele)-methylhistamine; 1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride; 1-methyl-4-(b-aminoethyl)imidazole; 1-methyl-4-(2-aminoethyl)-imidazole; 1H-Imidazole-4-ethanamine, 1-methyl-, hydrochloride (1:2); 2-(1-Methyl-1H-imidazol-4-yl)ethanamine dihydrochloride; 2-(1-methyl-imidazol-4yl)ethylamine; Tele-methylhistamine; 1-Methyl-4-histamine; 1-Methyl-1H-imidazole-4-ethanamine; 1H-Imidazole-4-ethanamine,1-methyl; 2-(1-methyl-1H-imidazol-4-yl)ethylamine; Ntau-Methylhistamine

物化性质

• 密度: 1.11g/cm3
• 沸点: 296.7ºC at 760mmHg
• 分子式: C₆H₁₁N₃
• 分子量: 125.17
• 闪点: 133.2ºC
• PSA: 43.84000
• LogP: 2.22560

生物活性

• 描述: 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine 是一种组胺 (Him) 代谢物。
• 相关类别:
  天然产物 >> 其他
  研究领域 >> 其他
• 靶点:

  Human Endogenous Metabolite

• 体外研究: 2-(1-甲基-1H-咪唑-4-基)乙-1-胺(1-甲基组胺)是组胺代谢物。它是组胺1-甲基转移酶在组氨酸代谢途径中的产物。
• 参考文献:

  [1]. Saito K, et al. Determination of urinary excretion of histamine and 1-methylhistamine by liquid chromatography. J Chromatogr B Biomed Appl. 1994 Apr 1;654(2):270-5.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NI3505500 CHEMICAL NAME : 1H-Imidazole, 4-(1-aminoethyl)-1-methyl- CAS REGISTRY NUMBER : 501-75-7 BEILSTEIN REFERENCE NO. : 0110757 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C6-H11-N3 MOLECULAR WEIGHT : 125.20 WISWESSER LINE NOTATION : T5N CNJ A1 D2Z HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 100 umol/L REFERENCE : JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975

安全

• 海关编码: 2933290090

合成路线

51720-37-7 ~% 501-75-7

文献：Arcari; Bernardi; Cimaschi; Falconi; Luini; Scarponi Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 p. 1467 - 1471

51-45-6 ~% 501-75-7

文献：Nordlander; Zhivich; Koldobskii; Dubinskii Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1825 - 1826

41065-00-3 ~% 501-75-7

文献：Pyman Journal of the Chemical Society, 1911 , vol. 99, p. 2181

18502-05-1 ~% 501-75-7

文献：Pyman Journal of the Chemical Society, 1911 , vol. 99, p. 2181

673-49-4 77-78-1 ~% 501-75-7 644-42-8

文献：Rothschild; Schayer Biochimica et Biophysica Acta, 1958 , vol. 30, p. 23,24

14509-66-1 ~% 501-75-7

文献：Nordlander; Zhivich; Koldobskii; Dubinskii Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1825 - 1826

海关

海关编码	2933290090
中文概述	2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%