39800-28-7

• 常用中文名：4-过氧化氢异环磷酰胺
• 常用英文名：2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide
• CAS号：39800-28-7
• 分子式：C₇H₁₅Cl₂N₂O₄P
• 分子量：293.08
• 相关类别： 研究领域 癌症
• 发布时间：2018-04-27 08:00:00
• 更新时间：2024-01-12 07:05:48
• 4-过氧化氢一磷酰胺是一种可以穿透血脑屏障(BBB)的抗癌剂[1]。

名称

• 中文名: 4-过氧化氢异环磷酰胺
• 英文名: 4-hydroperoxyifosfamide
• 英文别名: Hydroperoxyisophosphamide; 4-Hydroperoxyisophosphamid; 4-Hydroperoxyifosfamid; asta6760; 4-hydroperoxyisophosphamide

物化性质

• 密度: 1.46g/cm3
• 沸点: 419.9ºC at 760mmHg
• 分子式: C₇H₁₅Cl₂N₂O₄P
• 分子量: 293.08
• 闪点: 207.8ºC
• 精确质量: 292.01500
• PSA: 80.84000
• LogP: 2.02850
• 折射率: 1.525

生物活性

• 描述: 4-过氧化氢一磷酰胺是一种可以穿透血脑屏障(BBB)的抗癌剂[1]。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Ishimoto TM, et al. Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. Pharmacogenetics. 2002 Oct;12(7):543-53.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MX2435000 CHEMICAL NAME : Hydroperoxide, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro- 2H-1,3,2-oxazaphospho rin- 4-yl-, P-oxide CAS REGISTRY NUMBER : 39800-28-7 LAST UPDATED : 199310 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C7-H15-Cl2-N2-O4-P MOLECULAR WEIGHT : 293.11 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 230 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 230 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976