22089-22-1

• 常用中文名：曲磷胺
• 常用英文名：Trofosfamide
• CAS号：22089-22-1
• 分子式：C₉H₁₈Cl₃N₂O₂P
• 分子量：323.584
• 相关类别： 研究领域 癌症
• 发布时间：2018-04-04 08:00:00
• 更新时间：2024-01-12 07:48:34
• Trofosfamide 是一种有口服生物活性的氧氮磷环类衍生物,具有抗癌活性。

名称

• 中文名: 曲磷胺
• 英文名: Trofosfamide
• 英文别名: 3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide (9CI); 2-[Bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-Oxide; 3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine 2-oxide; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide; N,N,3-Tris(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide; Asta Z 4828; A-4828; TROPHOSPHAMIDE; Trofosfamide; ifosfamide mustard; 2-(Bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; Trilophosphamide; triphosphamide; N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-Oxide; 2H-1,3,2-Oxazaphosphorin-2-amine,N,N,3-tris(2-chloroethyl)tetrahydro-,2-oxide (9ci)

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 393.7±52.0 °C at 760 mmHg
• 分子式: C₉H₁₈Cl₃N₂O₂P
• 分子量: 323.584
• 闪点: 191.9±30.7 °C
• 精确质量: 322.017151
• PSA: 42.59000
• LogP: 1.77
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.519

生物活性

• 描述: Trofosfamide 是一种有口服生物活性的氧氮磷环类衍生物,具有抗癌活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Witte HM, et al. Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2019 Jan;145(1):129-136.

  [2]. Görn M, et al. A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC). Onkologie. 2008 Apr;31(4):185-9.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RP5880000 CHEMICAL NAME : 2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahyd ro-, 2-oxide CAS REGISTRY NUMBER : 22089-22-1 LAST UPDATED : 199612 DATA ITEMS CITED : 25 MOLECULAR FORMULA : C9-H18-Cl3-N2-O2-P MOLECULAR WEIGHT : 323.61 WISWESSER LINE NOTATION : T6NTJ A1 DOV1- ET5OVXTJ ER& C-& AL6XTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - hematuria Blood - leukopenia Blood - thrombocytopenia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 202 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 210 mg/kg TOXIC EFFECTS : Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 464 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 212 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 157 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Micronucleus test TYPE OF TEST : Specific locus test TYPE OF TEST : Dominant lethal test TYPE OF TEST : Sperm Morphology TYPE OF TEST : Heritable translocation test MUTATION DATA TEST SYSTEM : Rodent - hamster DOSE/DURATION : 3300 ug/kg REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 38,35,1977

安全

• 海关编码: 2934999090

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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%