3564-09-8

• 常用中文名：丽春红3R
• 常用英文名：PONCEAU 3R
• CAS号：3564-09-8
• 分子式：C₁₉H₁₆N₂Na₂O₇S₂
• 分子量：494.45
• 相关类别： 分析化学 标准品 食品和饮料标准品
• 发布时间：2018-07-17 19:12:51
• 更新时间：2024-01-02 22:00:10
• 胭脂红3R是一种偶氮染料,可用作食品着色剂[1]。

名称

• 中文名: 丽春红3R
• 英文名: ponceau 3r
• 中文别名: 3-羟基-4-[(2,4,5-三甲苯基)偶氮]-2,7-萘二磺酸二钠; 1-(2,4,5-三甲基苯)-2-萘酚-3,6-二磺酸二钠盐
• 英文别名: AKA502; FDandC Rot Nr.1; MFCD00036432; ponceaurn; fdcred1; EINECS 222-638-0; disodium 3-hydroxy-4-[(2,4,5-trimethylphenyl)azo]naphthalene-2,7-disulfonate; afredno1; dandcred15; ponceau3rn; cifood6; Poncean 3R Di-Na-Salz; ACIDDYE

物化性质

• 分子式: C₁₉H₁₆N₂Na₂O₇S₂
• 分子量: 494.45
• 精确质量: 494.01900
• PSA: 176.11000
• LogP: 5.85580
• 储存条件:

  避光，通风干燥处，密封保存

• 稳定性:

  常温常压下稳定

• 分子结构:

  1、摩尔折射率：无可用的

  2、摩尔体积（cm³/mol）：无可用的

  3、等张比容（90.2K）：无可用的

  4、表面张力（dyne/cm）：无可用的

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：无可用的

  7、单一同位素质量：494.019431Da

  8、标称质量：494Da

  9、平均质量：494.4491Da

• 计算化学:

  1、 氢键供体数量：1

  2、 氢键受体数量：9

  3、 可旋转化学键数量：2

  4、 互变异构体数量：3

  5、 拓扑分子极性表面积（TPSA）：156

  6、 重原子数量：32

  7、 表面电荷：0

  8、 复杂度：933

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：1

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：3

• 更多:

  1. 性状：未确定

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: 胭脂红3R是一种偶氮染料,可用作食品着色剂[1]。
• 相关类别:
  研究领域 >> 其他
• 参考文献:

  [1]. Hartman CP, et al. Production of a mutagen from ponceau 3R by a human intestinal anaerobe. Infect Immun. 1979 Mar;23(3):686-9.

MSDS

Section 1. Chemical Product and Company Identification Ponceau 3RCatalog PO144 Common Name/ Number(s). Trade Name CAS#3564-09-8 Manufacturer RTECSQJ6650000 SPECTRUM CHEMICAL MFG. CORP. TSCATSCA 8(b) inventory: No products were found. Commercial Name(s)Cumidine Red CI# 16155 Synonym3-Hydroxy-4-[(2,4,5-trimethylphenyl)azo]-2,7-naphthalenedisulfonic IN CASE OF EMERGENCY acid disodium salt Chemical NameNot available. Not available.CALL (310) 516-8000 Chemical Family Chemical FormulaC19H10N2Na2O7S2 SPECTRUM CHEMICAL MFG. CORP. Section 2.Composition and Information on Ingredients Exposure Limits TWA (mg/m3)STEL (mg/m3) CEIL (mg/m3) NameCAS #% by Weight 1) Ponceau 3R3564-09-8100 Toxicological DataPonceau 3R on IngredientsLD50: Not available. LC50: Not available. Section 3. Hazards Identification Potential Acute Health Effects Very hazardous in case of ingestion, of inhalation. Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant). Potential Chronic HealthVery hazardous in case of ingestion, of inhalation. EffectsHazardous in case of skin contact (irritant, permeator), of eye contact (irritant). CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Ponceau 3R Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. Do not use an eye ointment. Seek medical attention. Skin ContactAfter contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Serious Skin ContactWash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. InhalationAllow the victim to rest in a well ventilated area. Seek immediate medical attention. Serious InhalationNot available. IngestionDo not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention. Serious Ingestion Not available. Section 5. Fire and Explosion Data Flammability of the Product Non-flammable. Auto-Ignition Temperature Not applicable. Not applicable. Flash Points Not applicable. Flammable Limits Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...). Some metallic oxides. Not available. Fire Hazards in Presence of Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillFinish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Ponceau 3R Section 7. Handling and Storage PrecautionsKeep locked up Do not breathe gas/fumes/ vapour/spray. Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the label when possible. Keep container tightly closed and in a well-ventilated place. Avoid contact with skin and eyes StorageCarcinogenic, teratogenic or mutagenic materials should be stored in a separate locked safety storage cabinet or room. Section 8. Exposure Controls/Personal Protection Engineering ControlsNo special ventilation requirements. Personal ProtectionSplash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Not available.OdorNot available. TasteNot available. Molecular Weight494.46 g/mole Not available. Color Not available. pH (1% soln/water) Boiling PointNot available. Decomposes. Melting Point Critical TemperatureNot available. Specific GravityNot available. Vapor PressureNot available. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Not available. Water/Oil Dist. Coeff. Ionicity (in Water)Not available. Dispersion PropertiesNot available. SolubilityNot available. Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityNot available. Incompatibility with variousNot available. substances CorrosivityNon-corrosive in presence of glass. Ponceau 3R Not available. Special Remarks on Reactivity Special Remarks onNot available. Corrosivity PolymerizationNo. Section 11. Toxicological Information Routes of EntryDermal contact. Eye contact. Inhalation. Ingestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC. Other Toxic Effects on Very hazardous in case of ingestion, of inhalation. HumansHazardous in case of skin contact (irritant, permeator). Special Remarks on Not available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherNot available. Toxic Effects on Humans Section 12. Ecological Information EcotoxicityNot available. Not available. BOD5 and COD Possibly hazardous short term degradation products are not likely. However, long term degradation products may Products of Biodegradation arise. Toxicity of the ProductsThe products of degradation are more toxic. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste Disposal Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Not applicable. Special Provisions for Transport DOT (Pictograms) Ponceau 3R Section 15. Other Regulatory Information and Pictograms California prop. 65: This product contains the following ingredients for which the State of California has found to Federal and State cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Ponceau Regulations 3R California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: Ponceau 3R Pennsylvania RTK: Ponceau 3R Massachusetts RTK: Ponceau 3R CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: Ponceau 3R Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsNot available.. WHMIS (Canada) CLASS D-2A: Material causing other toxic effects (VERY TOXIC). Other Classifications DSCL (EEC)R36/38- Irritating to eyes and skin. R40- Possible risks of irreversible effects. Health Hazard HMIS (U.S.A.)2 National Fire Protection 0 Flammability 0 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection h WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Ponceau 3R Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、 致肿瘤数据： 大鼠口经TDLo：730 gm/kg/2Y-C 小鼠口经TDLo：1640 gm/kg/65W-C 小鼠注射TDLo：80mg/kg 小鼠口经TD：1140 gm/kg/68W-C 大鼠口经TD：200 gm/kg/24W-C 2、 致突变数据： 突变microorganismsTEST系统：细菌-鼠伤寒沙门氏菌：660 nmol/plate 突变测试系统-而非specifiedTEST系统：细菌-大肠杆菌：300 umol/L 突变microorganismsTEST系统：啮齿动物-小鼠淋巴细胞：1701 mg/L 生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : QJ6650000 CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-, disodium salt CAS REGISTRY NUMBER : 3564-09-8 LAST UPDATED : 199709 DATA ITEMS CITED : 19 MOLECULAR FORMULA : C19-H16-N2-O7-S2.2Na MOLECULAR WEIGHT : 494.47 WISWESSER LINE NOTATION : L66J BNUNR B1 D1 E1& CQ DSWQ HSWQ &-NA- 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 730 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1640 gm/kg/65W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1140 gm/kg/68W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 gm/kg/24W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 1701 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 189,223,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,199,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,199,1975 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83806 No. of Facilities: 131 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 827 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83806 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 36 (estimated) No. of Female Employees: 16 (estimated)

安全

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H302-H315-H319-H335-H351
• 警示性声明: P261-P281-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S22-S36/37/39
• 危险品运输编码: NONH for all modes of transport
• RTECS号: QJ6650000