900-95-8

900-95-8结构式

常用中文名：三苯基乙酸锡
常用英文名：FENTIN ACETATE
CAS号：900-95-8
分子式：C₂₀H₁₈O₂Sn
分子量：409.066
相关类别：有机原料有机金属类化合物有机锡
发布时间：2018-07-30 16:46:17
更新时间：2024-01-02 18:45:16
Fentin acetate is an organotin compound. Triphenyltin Acetate much like its hydroxide analogue is used as a fungicide and antifeeding compound for insect control. Recent studies show that Triphenyltin Acetate may have adverse effects on the reproductive and immune systems and may disrupt the endocrine system.

中文名	三苯基乙酸锡
英文名	fentin acetate
中文别名	三苯基醋酸锡三苯基锡醋酸三苯基锡
英文别名	Acetoxytriphenyltin tri(phenyl)tin ethanoate Stannane, acetoxytriphenyl- Tin, acetoxytriphenyl- Triphenyltin acetate FENTIN ACETATE EINECS 212-984-0 (acetyloxy)(triphenyl)stannane Triphenylstannanylium acetate (Acetyloxy)triphenylstannane Acetoxy-triphenylstannane Stannanylium, triphenyl- acetate (1:1) tri(phenyl)tin acetate triphenylstannyl acetate MFCD00014977 Fenolovo acetate Triphenyltin hydroxide acetate Acetoxytriphenylstannane Triphenylstannylium acetate

密度	1.55
熔点	118-122°C
分子式	C₂₀H₁₈O₂Sn
分子量	409.066
精确质量	410.032867
PSA	26.30000
LogP	2.21660
外观性状	白色晶体
储存条件	保持容器密封，储存在阴凉，干燥的地方
稳定性	常温常压下稳定，避免氧化物酸接触
水溶解性	28 mg/L (20 ºC)
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:2 4.可旋转化学键数量:5 5.互变异构体数量:无 6.拓扑分子极性表面积26.3 7.重原子数量:23 8.表面电荷:0 9.复杂度:332 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：白色无味结晶粉末 2. 密度（g/mL,25/4℃）：1.55 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：118～122℃ 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（30℃）：0.177×10^-3Pa 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：能微溶于大多数有机溶剂，在水中溶解度为28mg/L

国标编号:	61884
ＣＡＳ:	900-95-8
中文名称:	薯瘟锡
英文名称:	Fentin-acetate
别名:	乙酸三苯基锡；乙酰氧基三苯基锡
分子式:	C₂₀H₁₈O₂Sn
分子量:	409.07
熔点:	121～124℃
密度:	1.55
蒸汽压:	30℃
溶解性:	几乎不溶于水，微溶于大多数有机溶剂
稳定性:	暴露于空气和阳光下较易分解，干燥时稳定，遇水分解在
外观与性状:	白色结晶，无味
危险标记:	15(有害品，远离食品)
用途:	用作农用杀菌剂

2.对环境的影响:
一、健康危害

侵入途径：吸入、食入、经皮吸收。
健康危害：主要引起神经系统的损害。其临床表现有头痛、头晕、精神萎靡、乏力、恶心、食欲减退等。对皮肤可引起接触性皮炎、过敏性皮炎。长期接触，可引起神经衰弱综合征。

二、毒理学资料及环境行为

毒性：属中等毒类。
急性毒性：LD50125mg/kg(大鼠经口)；81.3mg/kg(小鼠经口)；人吸入125mg/kg，2小时，呼吸系统，神经系统和胃肠道功能有变化；人经皮肤接触125mg/kg2天，有皮肤刺激，肝、胆炎症。
亚急性和慢性毒性：豚鼠经口0.25mg/kg×90天，血液系统和中枢神经系统改变，死亡。

危险特性：遇明火、高热可燃。受高热分解放出有毒的气体。
燃烧(分解)产物：一氧化碳、二氧化碳、氧化锡。

3.现场应急监测方法:
　

4.实验室监测方法:
定量测定三苯基锡杀菌剂的生物色谱法{刊，英]/Adinarayana M.；Singh U.S.；Dwivedi T.S.//J.Chromatogr.-1988，435(1).-210～218 《分析化学文摘》1989.6

5.环境标准:
美国车间卫生标准 0.1mg/m3(皮)(锡)
食物中最高残留限值(特定农作物)：0.1-1.0mg/kg(1978)

6.应急处理处置方法:
一、泄漏应急处理

隔离泄漏污染区，周围设警告标志，建议应急处理人员戴自给式呼吸器，穿化学防护服。避免扬尘，小心扫起，收集运至废物处理场所。也可以用大量水冲洗，经稀释的洗水放入废水系统。对污染地带进行通风。如大量泄漏，收集回收或无害处理后废弃。

二、防护措施

呼吸系统防护：可能接触毒物时，应该佩戴防毒口罩。空气中浓度较高时，佩戴自给式呼吸器。
眼睛防护：可采用安全面罩。
身体防护：穿相应的防护服。
手防护：戴防护手套。
其它：工作现场严禁吸烟、进食和饮水。工作后，淋浴更衣。工作服不要带到非作业场所，单独存放被毒物污染的衣服，洗后再用。注意个人清洁卫生。

三、急救措施

皮肤接触：用肥皂水及清水彻底冲洗。就医。
眼睛接触：拉开眼睑，用流动清水冲洗15分钟。就医。
吸入：脱离现场至空气新鲜处。就医。
食入：误服者，饮适量温水，催吐。就医。

灭火方法：泡沫、干粉、砂土。

毒理学数据:

1、急性毒性：小鼠口经LD50：81mg/kg；大鼠口经LD50：125mg/kg

2、急性毒性：小鼠腹腔LD50：7900ug/kg；大鼠腹腔LD50：8500ug/kg

3、急性毒性：小鼠静脉LD50：18mg/kg；大鼠静脉LD50：18mg/kg

生态学数据:

对水是极其危害的，即使是小量的产品渗入地下也会对饮用水造成危险若无政府许可，勿将材料排入周围环境

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH6650000

CHEMICAL NAME :: Stannane, acetoxytriphenyl-

CAS REGISTRY NUMBER :: 900-95-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 55

MOLECULAR FORMULA :: C20-H18-O2-Sn

MOLECULAR WEIGHT :: 409.07

WISWESSER LINE NOTATION :: 1VO-SN-R&R&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 81 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7900 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3740 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 320 mg/kg/4W-I

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5350 mg/kg/15W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1276 mg/kg/4D-C

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 9600 ug/kg/4W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 132 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 99 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 380 mg/kg

SEX/DURATION :: male 19 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 54 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,5,1993 *** REVIEWS *** ACGIH TLV-TWA 0.1 mg(Sn)/m3;STEL 0.2 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,61,1973 TOXICOLOGY REVIEW EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued. Volume(issue)/page/year: 4,80,1975 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.1 mg(Sn)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,258,1971 OSHA PEL (Gen Indu):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.1 mg(Sn)/m3;STEL 0.3 mg(Sn)/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-HUNGARY:STEL 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 mg(Sn)/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993 OEL-THAILAND:TWA 0.1 mg(Sn)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ORGANOTIN COMPOUND-air:10H TWA 0.1 mg(Sn)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

符号	GHS05, GHS06, GHS08, GHS09
信号词	Danger
危害声明	H301 + H311-H315-H318-H330-H335-H351-H361d-H371-H372-H410
警示性声明	P201-P260-P273-P280-P304 + P340 + P310
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲)	T+:Verytoxic;N:Dangerous for the environment;
风险声明 (欧洲)	R24/25;R26;R37/38;R40;R41;R48/23;R50/53;R63
安全声明 (欧洲)	S26-S28-S36/37/39-S45-S60-S61
危险品运输编码	3146
RTECS号	WH6650000
包装等级	III
危险类别	6.1

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