27260-19-1

• 常用中文名：N-Desethyl Metoclopramide
• 常用英文名：N-Desethyl Metoclopramide
• CAS号：27260-19-1
• 分子式：C₁₂H₁₈ClN₃O₂
• 分子量：271.74300
• 发布时间：2016-01-31 09:22:22
• 更新时间：2024-01-06 14:15:21

名称

• 英文名: 4-Amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxybenzamide
• 英文别名: ethylethylenediamine-4-amino-5-chloro-2-methoxybenzoic acid amide; N-deethyl-Metoclopramide

物化性质

• 密度: 1.2g/cm3
• 沸点: 414.5ºC at 760 mmHg
• 分子式: C₁₂H₁₈ClN₃O₂
• 分子量: 271.74300
• 闪点: 204.5ºC
• 精确质量: 271.10900
• PSA: 79.87000
• LogP: 2.81700
• 蒸汽压: 4.41E-07mmHg at 25°C
• 折射率: 1.559

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BZ3330000 CHEMICAL NAME : o-Anisamide, 4-amino-5-chloro-N-(2-(ethylamino)ethyl)- CAS REGISTRY NUMBER : 27260-19-1 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C12-H18-Cl-N3-O2 MOLECULAR WEIGHT : 271.78 WISWESSER LINE NOTATION : 2M2MVR DZ CG FO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 242 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,649,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,649,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 245 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,649,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 41 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,649,1976

合成路线

110-72-5 7206-70-4 ~62% 27260-19-1

文献：NEKTAR THERAPEUTICS; CHENG, Lin; RIGGS-SAUTHIER, Jennifer; ANAND, Neel, K. Patent: WO2014/43707 A1, 2014 ; Location in patent: Paragraph 0166; 0167 ;

364-62-5 ~% 27260-19-1

文献：Monkovic, Ivo; Wong, Henry; Bachand, Carol Synthesis, 1985 , # 8 p. 770 - 773

171367-22-9 ~% 27260-19-1

文献：Monkovic, Ivo; Wong, Henry; Bachand, Carol Synthesis, 1985 , # 8 p. 770 - 773

上下游产品

上游产品  4
110-72-5 7206-70-4 364-62-5 171367-22-9
下游产品  0