71381-75-4

• 常用中文名：1-BOC-哌啶-3-羧酸
• 常用英文名：1,3-Piperidinedicarboxylicacid 1-tert-butyl ester
• CAS号：71381-75-4
• 分子式：C₁₁H₁₉NO₄
• 分子量：229.27300
• 发布时间：2018-03-12 08:00:00
• 更新时间：2024-01-07 16:38:19

名称

• 中文名: 1-BOC-哌啶-3-羧酸
• 英文名: 1-boc-piperidine-3-carboxylic acid
• 英文别名: BOC-DL-PIC(3)-OH; (s)-boc-nip-oh; rac-N-(t-butoxycarbonyl)piperidine-3-carboxylic acid; N-(tert-butyloxy-carbonyl)piperidine-3-carboxylic acid; (S)-BOC-NIP; (RS)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester; BOC-NIP-OH; N-BOC-nipecotic acid; BOC-NIP; BOC-(S)-NIP-OH; piperidine-1,3-dicarboxylic acid 1-tert-butyl ester; N-tert-butoxycarbonyl-3-piperidinecarboxylic acid; 1-(tert-butoxycarbonyl)-3-piperidine carboxylic acid; MFCD00673775; BOC-L-NIP-OH; BOC-DL-NIPC-OH; BOC-(R,S)-NIP-OH; BOC-DL-NIP-OH

物化性质

• 熔点: 159-162ºC(lit.)
• 分子式: C₁₁H₁₉NO₄
• 分子量: 229.27300
• 精确质量: 229.13100
• PSA: 66.84000
• LogP: 1.65600
• 储存条件: 2-8℃

安全

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36
• WGK德国: 3

合成路线

24424-99-5 498-95-3 ~95% 71381-75-4

文献：Zhang, Li; Qiu, Beiying; Xiong, Bing; Li, Xin; Li, Jingya; Wang, Xin; Li, Jia; Shen, Jingkang Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2118 - 2122

58632-95-4 498-95-3 ~79% 71381-75-4

文献：Crider; Tita; Wood; Hinko Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 11 p. 1214 - 1219

148672-74-6 ~99% 71381-75-4

文献：Villalgordo, Jose M.; Heimgartner, Heinz Tetrahedron, 1993 , vol. 49, # 33 p. 7215 - 7222

851956-01-9 24424-99-5 ~% 71381-75-4

文献：PIRAMED LIMITED Patent: WO2006/46031 A1, 2006 ; Location in patent: Page/Page column 81 ; WO 2006/046031 A1

73371-96-7 498-95-3 ~76% 71381-75-4

文献：Catalano, Alessia; Carocci, Alessia; Corbo, Filomena; Franchini, Carlo; Muraglia, Marilena; Scilimati, Antonio; De Bellis, Michela; De Luca, Annamaria; Camerino, Diana Conte; Sinicropi, Maria Stefania; Tortorella, Vincenzo European Journal of Medicinal Chemistry, 2008 , vol. 43, # 11 p. 2535 - 2540

24424-99-5 121-44-8 498-95-3 114214-69-6 ~% 详细

文献：Bayer Aktiengesellschaft Patent: US6562811 B1, 2003 ;

24424-99-5 ~% 71381-75-4

文献：Villalgordo, Jose M.; Heimgartner, Heinz Tetrahedron, 1993 , vol. 49, # 33 p. 7215 - 7222

71962-74-8 ~% 71381-75-4

文献：Villalgordo, Jose M.; Heimgartner, Heinz Tetrahedron, 1993 , vol. 49, # 33 p. 7215 - 7222

上下游产品

上游产品  8
24424-99-5 498-95-3 58632-95-4 851956-01-9
73371-96-7 121-44-8 114214-69-6 71962-74-8
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35090-94-9 91419-53-3 40576-21-4 50585-89-2
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