81965-43-7

• 常用中文名：Sarcosinamide chloroethylnitrosourea
• 常用英文名：Sarcosinamide chloroethylnitrosourea
• CAS号：81965-43-7
• 分子式：C₆H₁₁ClN₄O₃
• 分子量：222.63000
• 发布时间：2016-07-24 00:00:47
• 更新时间：2024-02-25 21:26:40

名称

• 英文名: 2-[[2-chloroethyl(nitroso)carbamoyl]-methylamino]acetamide
• 英文别名: Sarcosinamide chloroethylnitrosourea; 2-Chloroethyl-3-sarcosinamide-1-nitrosourea; Sarmustine; Sarcnu

物化性质

• 密度: 1.45g/cm3
• 沸点: 378.1ºC at 760 mmHg
• 分子式: C₆H₁₁ClN₄O₃
• 分子量: 222.63000
• 闪点: 182.5ºC
• 精确质量: 222.05200
• PSA: 96.07000
• LogP: 0.44600
• 折射率: 1.569

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YS4552800 CHEMICAL NAME : Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitr oso- CAS REGISTRY NUMBER : 81965-43-7 LAST UPDATED : 198909 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C6-H11-Cl-N4-O3 MOLECULAR WEIGHT : 222.66 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 392 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 427 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982

合成路线

81965-42-6 ~82% 81965-43-7

文献：Suami; Kato; Takino; Hisamatsu Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 829 - 832

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