70146-78-0

• 常用中文名：2-(4-溴苄基)丙二酸二乙酯
• 常用英文名：Diethyl-(4-brombenzyl)malonat
• CAS号：70146-78-0
• 分子式：C₁₄H₁₇BrO₄
• 分子量：329.186
• 发布时间：2018-12-25 11:14:58
• 更新时间：2024-01-03 17:38:02

名称

• 中文名: 2-(4-溴苄基)-丙二酸二乙酯
• 英文名: diethyl 2-[(4-bromophenyl)methyl]propanedioate
• 中文别名: 2-(4-溴苯基)-丙二酸二乙酯
• 英文别名: Diethyl (4-bromobenzyl)malonate; Diethyl-(4-brombenzyl)malonat; Propanedioic acid, 2-[(4-bromophenyl)methyl]-, diethyl ester

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 375.7±27.0 °C at 760 mmHg
• 分子式: C₁₄H₁₇BrO₄
• 分子量: 329.186
• 闪点: 181.0±23.7 °C
• 精确质量: 328.031006
• PSA: 52.60000
• LogP: 3.53
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.523
• 储存条件: 室温，干燥密封

合成路线

589-15-1 105-53-3 ~82% 70146-78-0

文献：VITAE PHARMACEUTICALS, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CACATIAN, Salvacion; CLAREMON, David, A.; DILLARD, Lawrence, W.; FUCHS, Klaus; HEINE, Niklas; JIA, Lanqi; LEFTHERIS, Katerina; MCKEEVER, Brian; MORALES-RAMOS, Angel; SINGH, Suresh; VENKATRAMAN, Shankar; WU, Guosheng; WU, Zhongren; XU, Zhenrong; YUAN, Jing; ZHENG, Yajun Patent: WO2010/105179 A2, 2010 ; Location in patent: Page/Page column 76 ; WO 2010/105179 A2

589-17-3 105-53-3 ~49% 70146-78-0

文献：Ward, Richard A.; Brassington, Claire; Breeze, Alexander L.; Caputo, Alessandro; Critchlow, Susan; Davies, Gareth; Goodwin, Louise; Hassall, Giles; Greenwood, Ryan; Holdgate, Geoffrey A.; Mrosek, Michael; Norman, Richard A.; Pearson, Stuart; Tart, Jonathan; Tucker, Julie A.; Vogtherr, Martin; Whittaker, David; Wingfield, Jonathan; Winter, Jon; Hudson, Kevin Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3285 - 3306

105-53-3 ~% 70146-78-0

文献：Huang, Wen; Zheng, Pengzhi; Zhang, Zhengxing; Liu, Rutting; Chen, Zhenxia; Zhou, Xigeng Journal of Organic Chemistry, 2008 , vol. 73, # 17 p. 6845 - 6848

107558-73-6 ~% 70146-78-0

文献：Kuwabara, Kenji; Aoki, Tomiyoshi Patent: US2003/166697 A1, 2003 ;

上下游产品

上游产品  4
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