86386-76-7

• 常用中文名：1-[2-(2,4-二氟苯基)-2,3-环氧基丙基]-1H-1,2,4-噻唑
• 常用英文名：1-{[2-(2,4-DIFLUOROPHENYL)OXIRAN-2-YL]METHYL}-1H-1,2,4-TRIAZOLE
• CAS号：86386-76-7
• 分子式：C₁₁H₉F₂N₃O
• 分子量：237.20500
• 发布时间：2018-11-27 00:37:42
• 更新时间：2024-01-09 18:32:56

名称

• 中文名: 1-[2-(2,4-二氟苯基)-2,3-环氧基丙基]-1H-1,2,4-噻唑
• 英文名: 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1h-1,2,4-triazole
• 中文别名: 1-[[2-(2,4-二氟苯基)-2-环氧乙烷]甲基]-1H-1,2,4-三唑
• 英文别名: 2-(2,4-Difluorophenyl)-2,3-epoxy-1-(1H-1,2,4-triazol-1-yl)propane; Fluconazole Epoxy IMpurity; 2-[(1H-1,2,4-triazol-1-yl)methyl]-2-(2,4-difluorophenyl)oxirane; 1-(2-(2,4-difluorophenyl)oxiran-2-yl)methyl-1H-1,2,4-triazole; l-[2-(2,4-Difluoro Phenyl)Oxiranyl] Methyl-lH-1,2,4-Triazole; 1-[[2-(2,4-difluorophenyl)oxiranyl]methyl]-1H-1,2,4-triazole; 2-(2,4-Difluorophenyl)-2-[(1H-1,2,4-triazol-1-yl)Methyl]oxirane; 1,2-epoxy-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)-propane

物化性质

• 密度: 1.464g/cm3
• 沸点: 370.474ºC at 760 mmHg
• 分子式: C₁₁H₉F₂N₃O
• 分子量: 237.20500
• 闪点: 177.857ºC
• 精确质量: 237.07100
• PSA: 43.24000
• LogP: 1.48200
• 折射率: 1.625

合成路线

1774-47-6 86404-63-9 ~97% 86386-76-7

文献：Lebouvier, Nicolas; Giraud, Francis; Corbin, Typhanie; Na, Young Min; Le Baut, Guillaume; Marchand, Pascal; Le Borgne, Marc Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6479 - 6483

2181-42-2 86404-63-9 ~39% 86386-76-7

文献：Wang, Yan; Damu, Guri L.V.; Lv, Jing-Song; Geng, Rong-Xia; Yang, Da-Cheng; Zhou, Cheng-He Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5363 - 5366

1030268-24-6 86404-63-9 ~86% 86386-76-7

文献：Chai, Xiaoyun; Zhang, Jun; Hu, Honggang; Yu, Shichong; Sun, Qingyan; Dan, Zhigang; Jiang, Yuanying; Wu, Qiuye European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 1913 - 1920

86404-63-9 ~53% 86386-76-7

文献：Chai, Xiaoyun; Yu, Shichong; Jiang, Yongwei; Zou, Yan; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Cao, Yongbing; Sun, Qingyan Archives of Pharmacal Research, 2012 , vol. 35, # 11 p. 1895 - 1901

51336-94-8 ~% 86386-76-7

文献：Tetrahedron Letters, , vol. 47, # 36 p. 6479 - 6483

372-18-9 ~% 86386-76-7

文献：Journal of Medicinal Chemistry, , vol. 49, # 8 p. 2512 - 2525

70775-39-2 86404-63-9 ~% 86386-76-7

文献：Chemical and Pharmaceutical Bulletin, , vol. 51, # 9 p. 1113 - 1116

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