977-79-7

• 常用中文名：美屈孕酮
• 常用英文名：Medrogestone
• CAS号：977-79-7
• 分子式：C₂₃H₃₂O₂
• 分子量：340.49900
• 发布时间：2018-09-25 10:36:12
• 更新时间：2024-01-02 19:02:46

名称

• 中文名: 美屈孕酮
• 英文名: Medrogestone
• 中文别名: 二甲脱氢孕酮; 美罗孕酮
• 英文别名: EINECS 213-555-0; 4,6-PREGNADIEN-6,17-DIMETHYL-3,20-DIONE; 6,17-Dimethyl-4,6-pregnadien-3.20-dion; MFCD00271888; 6,17-Dimethyl-pregnadien-(4,6)-dion-(3.20); 6,17-Dimethyl-pregna-4,6-dien-3.20-dion; 6,17-dimethylpregna4,6-diene-3,20-dione

物化性质

• 密度: 1.08g/cm3
• 沸点: 467.2ºC at 760mmHg
• 分子式: C₂₃H₃₂O₂
• 分子量: 340.49900
• 闪点: 173.7ºC
• 精确质量: 340.24000
• PSA: 34.14000
• LogP: 5.27970
• 折射率: 1.549

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU3832300 CHEMICAL NAME : Pregna-4,6-diene-3,20-dione, 6,17-dimethyl- CAS REGISTRY NUMBER : 977-79-7 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C23-H32-O2 MOLECULAR WEIGHT : 340.55 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 850 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4230702 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 20500 ug/kg SEX/DURATION : female 1 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,473,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 300 mg/kg SEX/DURATION : female 15-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,473,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 26250 ug/kg SEX/DURATION : female 21 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,473,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 7500 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,473,1966

合成路线

20867-46-3 ~% 977-79-7

文献：J. Med. Chem., , vol. 6, p. 301 - 304

96618-99-4 ~% 977-79-7

文献：J. Med. Chem., , vol. 6, p. 301 - 304

106598-97-4 ~% 977-79-7

文献：Tetrahedron, , vol. 19, p. 289 - 298

25352-87-8 ~% 977-79-7

文献：Tetrahedron, , vol. 19, p. 289 - 298

2857-66-1 ~% 977-79-7

文献：Tetrahedron, , vol. 19, p. 289 - 298

5087-55-8 ~% 977-79-7

文献：Tetrahedron, , vol. 19, p. 289 - 298

75-16-1 3271-74-7 ~% 977-79-7

文献：Tetrahedron, , vol. 19, p. 289 - 298

上下游产品

上游产品  6
20867-46-3 106598-97-4 25352-87-8 5087-55-8
75-16-1 3271-74-7
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