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59-63-2生产厂家

59-63-2价格

相关CAS号：
59-63-2 17391-09-2
3019-51-0 66195-31-1
1013621-79-8 126040-58-2
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1221158-13-9 66608-32-0

59-63-2

59-63-2结构式
59-63-2结构式
  • 常用中文名：异卡波肼
  • 常用英文名：Isocarboxazid
  • CAS号：59-63-2
  • 分子式：C12H13N3O2
  • 分子量：231.251
  • 相关类别： 医药中间体 OLED材料中间体
  • 发布时间：2018-05-22 08:00:00
  • 更新时间：2024-01-08 18:38:29
  • Isocarboxazid 是一种非选择性的、不可逆的单胺氧化酶 monoamine oxidase 抑制剂,其在大鼠大脑中测得的 IC50 值为4.8 μM。

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中文名 异卡波肼
英文名 N'-benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
中文别名 异恶唑酰肼
英文别名 isocarboxazide
Benazide
5-Methyl-isoxazol-3-carbonsaeure-(N'-benzyl-hydrazid)
Marplan
Isocarboxazidum
N'-Benzyl-5-methylisoxazol-3-carbohydrazid
Isocarboxazida
3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide
N'-benzyl-5-méthylisoxazole-3-carbohydrazide
Isocarbonazid
Isocarboxazid
N'-benzyl-5-methylisoxazole-3-carbohydrazide
N-Benzyl-N'-<5-methyl-isoxazol-3-yl>-carbonyl-hydrazin
Isocarbossazide
N'-Benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
Isocarboxyzid
Enerzer
5-methyl-isoxazole-3-carboxylic acid-(N'-benzyl-hydrazide)
isocarboxacid
5-methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide
描述 Isocarboxazid 是一种非选择性的、不可逆的单胺氧化酶 monoamine oxidase 抑制剂,其在大鼠大脑中测得的 IC50 值为4.8 μM。
相关类别
靶点

IC50: 4.8 μM (rat brain monoamine oxidase)[1].
体内研究 在小鼠中预处理Isocarboxazid(1,3 mg/kg,腹膜内注射,60分钟)显示5-HTP后15和30分钟时头部抽搐的数量显着增加[2]。与单独使用5-HTP的小鼠相比,小鼠中的Isocarboxazid(1,3 mg/kg,ip,60 min)处理与5-HTP一起施用导致43％的5-HT浓度增加和22％的5-HIAA降低[2]。动物模型：12只雄性小鼠dd株(20-25g)[2]剂量：0,0.3,1,3mg/kg给药：腹腔注射60分钟,静脉注射5-HTP结果：头部抽搐数量5-HTP增加后15和30分钟。 43％的5-HT浓度增加,22％的5-HIAA减少。
参考文献

[1]. MAXWELL DR, et al. Relative activity of some inhibitors of mono-amine oxidase in potentiating the action of tryptamine in vitro and in vivo. Br J Pharmacol Chemother. 1961 Dec;17:310-20.
密度 1.2±0.1 g/cm3
沸点 394.5±42.0 °C at 760 mmHg
熔点 98-100ºC
分子式 C12H13N3O2
分子量 231.251
闪点 192.4±27.9 °C
精确质量 231.100784
PSA 67.16000
LogP 1.03
蒸汽压 0.0±0.9 mmHg at 25°C
折射率 1.573
储存条件 -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NY2625000
CHEMICAL NAME :
3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide
CAS REGISTRY NUMBER :
59-63-2
BEILSTEIN REFERENCE NO. :
0201295
LAST UPDATED :
199612
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C12-H13-N3-O2
MOLECULAR WEIGHT :
231.28
WISWESSER LINE NOTATION :
T5NOJ C1 EVMM1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
4800 ug/kg/21W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
199 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
193 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
138 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>40 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
130 mg/kg
SEX/DURATION :
female 10-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
100 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
DNA damage
TYPE OF TEST :
DNA damage

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
49 mg/kg
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 2,209,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6269 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 339 (estimated) No. of Female Employees: 170 (estimated)

符号 GHS06
GHS06
信号词 Danger
危害声明 H301
警示性声明 Missing Phrase - N15.00950417
危险品运输编码 UN 3249
包装等级 III
危险类别 6.1(b)
海关编码 2934999090
海关编码 2934999090
中文概述 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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