1187-59-3

• 常用中文名：N-甲基-2-丙烯酰胺
• 常用英文名：N-methylacrylamide
• CAS号：1187-59-3
• 分子式：C₄H₇NO
• 分子量：85.104
• 发布时间：2018-03-29 08:00:00
• 更新时间：2024-01-02 00:13:29

名称

• 中文名: N-甲基-2-丙烯酰胺
• 英文名: N-methylprop-2-enamide
• 英文别名: N-Methyl-2-propenamide; 2-Propenamide,N-methyl; N-methylprop-2-enamide; EINECS 214-700-0; (meth-)acrylamide; 2-Propenamide, N-methyl-; N-Methyl-acrylamid; N-Methylacrylamide; Acrylamide,N-methyl

物化性质

• 密度: 0.9±0.1 g/cm3
• 沸点: 207.7±13.0 °C at 760 mmHg
• 分子式: C₄H₇NO
• 分子量: 85.104
• 闪点: 103.6±4.8 °C
• 精确质量: 85.052765
• PSA: 29.10000
• LogP: -0.68
• 蒸汽压: 0.2±0.4 mmHg at 25°C
• 折射率: 1.415
• 储存条件: 2-8°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:0.1

  2.氢键供体数量:1

  3.氢键受体数量:1

  4.可旋转化学键数量:1

  5.互变异构体数量:2

  6.拓扑分子极性表面积29.1

  7.重原子数量:6

  8.表面电荷:0

  9.复杂度:67.9

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1.密度（g/cm3）：0.89

  2.沸点（760 mmHg,ºC）：207.7

  3.闪点（ºC）：103.6

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AS3676000 CHEMICAL NAME : Acrylamide, N-methyl- CAS REGISTRY NUMBER : 1187-59-3 BEILSTEIN REFERENCE NO. : 1737696 LAST UPDATED : 199701 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C4-H7-N-O MOLECULAR WEIGHT : 85.12 WISWESSER LINE NOTATION : 1U1VM1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 476 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 477 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6500 mg/kg/13W-I TOXIC EFFECTS : Peripheral Nerve and Sensation - structural change in nerve or sheath Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - muscle weakness TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4988 mg/kg/18W-C TOXIC EFFECTS : Behavioral - muscle weakness TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2587 mg/kg/8W-I TOXIC EFFECTS : Related to Chronic Data - changes in testicular weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2544 mg/kg SEX/DURATION : male 16 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 595 gm/kg SEX/DURATION : male 5 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 595 gm/kg SEX/DURATION : male 5 week(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 596 mg/kg/5W (Continuous) REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,201,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1046 No. of Facilities: 122 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 367 (estimated)

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S23;S26;S36/S37/S39
• 危险品运输编码: UN 2810
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2924199090

合成路线

7087-68-5 814-68-6 ~% 1187-59-3

文献：US5607960 A1, ;

5450-85-1 ~% 1187-59-3

文献：Journal of the American Chemical Society, , vol. 71, p. 648,650

814-68-6 74-89-5 ~% 1187-59-3

文献：US2311548 , ;

6830-81-5 ~% 1187-59-3

文献：US2749355 , ;

57-57-8 74-89-5 ~% 1187-59-3

文献：GB648886 , ;

24685-31-2 ~% 1187-59-3

文献：Journal fuer Praktische Chemie (Leipzig), , vol. 318, p. 471 - 478

74-89-5 140-88-5 ~% 1187-59-3

文献：US2683741 , ;

74-89-5 74-86-2 ~% 1187-59-3

文献：US2773063 , ;

5450-85-1 ~% 1187-59-3 75-07-0 64-19-7

文献：Journal of the American Chemical Society, , vol. 71, p. 648,650

上下游产品

上游产品  9
7087-68-5 814-68-6 5450-85-1 74-89-5
6830-81-5 57-57-8 24685-31-2 140-88-5
74-86-2
下游产品  3
1001346-35-5 2680-03-7 50836-82-3

海关

海关编码	2924199090
中文概述	2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%