434-05-9

• 常用中文名：美替诺龙醋酸酯
• 常用英文名：Methenolone Acetate
• CAS号：434-05-9
• 分子式：C₂₂H₃₂O₃
• 分子量：344.488
• 发布时间：2018-06-13 09:50:18
• 更新时间：2024-01-02 12:09:39
• Metenolone醋酸盐是一种长效的蛋白同化激素，具有较低的雄激素特性。IC50 value:Target:Metenolone醋酸盐是一种天然存在的化合物，在驯养的怀孕猫科肾上腺腺体内发现。Metenolone醋酸盐用于口服给药。Methenolone醋酸盐可抑制下丘脑 - 垂体 - 性腺通路。[1] Methenolone醋酸盐作为口服制剂时，Methenolone不是17-α-烷基化，而是1-甲基化，便于提高口服生物利用度，且降低肝脏应力。[2]

名称

• 中文名: 美替诺龙醋酸酯
• 英文名: Methenolone Acetate
• 中文别名: 17β-羟基-1-甲基-5α-雄甾-1-烯-3-酮-17-醋酸酯
• 英文别名: Primobolan; Methenolone acetate; Primonabol; EINECS 207-097-0; Androst-1-en-3-one, 17-(acetyloxy)-1-methyl-, (5α)-; (5α)-1-Methyl-3-oxoandrost-1-en-17-yl acetate; Nibal; MFCD00864181; Methenolone (acetate)

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 441.2±45.0 °C at 760 mmHg
• 分子式: C₂₂H₃₂O₃
• 分子量: 344.488
• 闪点: 189.9±28.8 °C
• 精确质量: 344.235138
• PSA: 43.37000
• LogP: 4.93
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.536
• 储存条件: 2~8℃

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BV8408500 CHEMICAL NAME : 5-alpha-Androst-1-en-3-one, 17-beta-hydroxy-1-methyl-, acetate CAS REGISTRY NUMBER : 434-05-9 LAST UPDATED : 199309 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C22-H32-O3 MOLECULAR WEIGHT : 344.54 WISWESSER LINE NOTATION : L E5 B666 OV LUTJ A1 E1 FOV1 K1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 200 mg/kg SEX/DURATION : male 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,330,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 60 mg/kg SEX/DURATION : female 17-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : AVBIB9 Advances in the Biosciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1967- Volume(issue)/page/year: 13,71,1974

安全

• 危害码 (欧洲): Xi
• 海关编码: 2942000000

合成路线

1099-80-5 ~8% 434-05-9

文献：Torrini; Romeo Farmaco, Edizione Scientifica, 1980 , vol. 35, # 8 p. 681 - 683

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海关编码	2942000000