3476-50-4

• 常用中文名：Trimethylcolchicinic acid methyl ether
• 常用英文名：Trimethylcolchicinic acid methyl ether
• CAS号：3476-50-4
• 分子式：C₂₀H₂₃NO₅
• 分子量：357.40000
• 发布时间：2016-09-27 18:43:56
• 更新时间：2024-01-20 15:28:39
• Trimethylcolchicinic acid methyl ether, Antimitotic agent that intercepts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal.

名称

• 英文名: Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)
• 英文别名: N-deacethylcolchicine; N-deacetylcolchicine; trimethylcolchicinic acid methyl ether; deacetylcolchicine; Desacetylcolchicine

物化性质

• 密度: 1.25g/cm3
• 沸点: 626.6ºC at 760mmHg
• 分子式: C₂₀H₂₃NO₅
• 分子量: 357.40000
• 闪点: 287ºC
• 精确质量: 357.15800
• PSA: 80.01000
• LogP: 3.39450
• 折射率: 1.597

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0785000 CHEMICAL NAME : Colchicine, N-deacetyl- CAS REGISTRY NUMBER : 3476-50-4 BEILSTEIN REFERENCE NO. : 2822162 LAST UPDATED : 199707 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C20-H23-N-O5 MOLECULAR WEIGHT : 357.44 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JZ NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 46 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 49 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : Mutation test systems - not otherwise specified TYPE OF TEST : Mutation test systems - not otherwise specified MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 46 mg/kg REFERENCE : CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950

安全

• WGK德国: 3
• 海关编码: 2922509090

合成路线

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海关

海关编码	2922509090
中文概述	2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%