毒理学数据:
口服- 小鼠 LD50: 800 毫克/ 公斤
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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KI1420000
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CHEMICAL NAME :
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Ethane, 1,2-difluoro-1,1,2,2-tetrachloro-
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CAS REGISTRY NUMBER :
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76-12-0
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BEILSTEIN REFERENCE NO. :
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1740336
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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33
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MOLECULAR FORMULA :
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C2-Cl4-F2
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MOLECULAR WEIGHT :
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203.82
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WISWESSER LINE NOTATION :
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GXGFXGGF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Open irritation test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - guinea pig
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 27,332,1966
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TYPE OF TEST :
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Rinsed with water
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - guinea pig
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 27,332,1966 ** ACUTE TOXICITY DATA **
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2 pph/15M
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
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REFERENCE :
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HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 1,239,1982
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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800 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,54,1982
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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50 gm/m3/2H
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
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REFERENCE :
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TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued. Volume(issue)/page/year: 75,241,1963
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0520705 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1000 ppm/6H/31D-I
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 27,332,1966 *** REVIEWS *** ACGIH TLV-TWA 4170 mg/m3 (500 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 500 ppm (4170 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,249,1971 OSHA PEL (Gen Indu):8H TWA 500 ppm (4170 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 500 ppm (4170 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 500 ppm (4170 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 500 ppm (4170 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-BELGIUM:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-DENMARK:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-FINLAND:TWA 500 ppm (4170 mg/m3);STEL 625 ppm (5215 mg/m3) JAN 1993 OEL-FRANCE:TWA 500 ppm (4760 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (1690 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 500 ppm (4200 mg/m3);STEL 1000 ppm JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (834 mg/m3);STEL 100 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE-air:TWA 500 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 71447 No. of Facilities: 451 (estimated) No. of Industries: 8 No. of Occupations: 7 No. of Employees: 7803 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 71447 No. of Facilities: 95 (estimated) No. of Industries: 5 No. of Occupations: 5 No. of Employees: 1434 (estimated) No. of Female Employees: 191 (estimated)
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