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381247-99-0

381247-99-0结构式
381247-99-0结构式

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中文名 2-羟基-3-溴-5-乙酸酯吡啶
英文名 methyl 5-bromo-6-oxo-1H-pyridine-3-carboxylate
中文别名 5-溴-6-羟基烟酸甲酯
英文别名 Methyl5-bromo-6-hydroxynicotinate
5-bromo-6-hydroxy-nicotinic acid methyl ester
5-Brom-6-hydroxy-nicotinsaeure-methylester
methyl 5-bromo-6-hydroxynicotinate
3-pyridinecarboxylic acid, 5-bromo-6-hydroxy-, methyl ester
methyl 5-bromo-6-hydroxypyridine-3-carboxylate
methyl 5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylate
5-Bromo-6-hydroxy-3-pyridinecarboxylic acid methyl ester
methyl 5-bromo-6-hydroxynicotininate
Methyl 5-bromo-6-oxo-1,6-dihydro-3-pyridinecarboxylate
密度 1.7±0.1 g/cm3
沸点 338.5±37.0 °C at 760 mmHg
熔点 225-227℃
分子式 C7H6BrNO3
分子量 232.031
闪点 158.5±26.5 °C
精确质量 230.953094
PSA 59.42000
LogP 1.07
外观性状 Solid | White to pale brown
蒸汽压 0.0±0.8 mmHg at 25°C
折射率 1.591
储存条件 室温
Material Safety Data Sheet

Section1. Identification of the substance
Methyl 5-bromo-6-hydroxynicotinate
Product Name:
Synonyms:Methyl 3-bromo-2-hydroxypyridine-5-carboxylate

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340:IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405:Store locked up

Section3. Composition/information on ingredients.
Methyl 5-bromo-6-hydroxynicotinate
Ingredient name:
CAS number:381247-99-0

Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not specified
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C7H6BrNO3
Molecular weight:232.0

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A
危害码 (欧洲) Xi
海关编码 2933399090

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381247-99-0结构式

381247-99-0

文献:ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2009/106885 A1, 2009 ; Location in patent: Page/Page column 296-297 ; WO 2009/106885 A1

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381247-99-0

文献:CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, SeoHee; Oh, Jung Taek; Lee, JaeKwang; Lee, JaeWon; Bae, Suyeal; Ha, Nina; Lee, Sera Patent: US2014/31335 A1, 2014 ; Location in patent: Paragraph 0042; 0562; 0563 ;

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381247-99-0结构式

381247-99-0

文献:CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, SeoHee; Oh, Jung Taek; Lee, JaeKwang; Lee, JaeWon; Bae, Suyeal; Ha, Nina; Lee, Sera Patent: US2014/31335 A1, 2014 ;

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381247-99-0

文献:v. Pechmann Chemische Berichte, 1884 , vol. 17, p. 2399 Chemische Berichte, 1885 , vol. 18, p. 318

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381247-99-0结构式

381247-99-0

文献:Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Hebeisen, Paul; Nettekoven, Matthias; Sander, Ulrike Obst; Panousis, Constantinos G.; Roever, Stephan Patent: US2008/85906 A1, 2008 ; Location in patent: Page/Page column 15 ;
海关编码 2933399090
中文概述 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%