288154-16-5

• 常用中文名：4-苄氧基羰基氨基哌啶-1,4-二甲酸单叔丁基酯
• 常用英文名：4-benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
• CAS号：288154-16-5
• 分子式：C₁₉H₂₆N₂O₆
• 分子量：378.419
• 发布时间：2018-12-28 15:10:21
• 更新时间：2024-01-03 14:22:50

名称

• 中文名: 1-Boc-4-(Cbz-氨基)哌啶-4-甲酸
• 英文名: 1-[(2-methylpropan-2-yl)oxycarbonyl]-4-(phenylmethoxycarbonylamino)piperidine-4-carboxylic acid
• 中文别名: 4-苄氧基羰基氨基哌啶-1,4-二甲酸单叔丁基酯
• 英文别名: 4-benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester; 1-Boc-4-(Cbz-amino)piperidine-4-carboxylic Acid; z-pip(boc)-oh; 1-boc-4-n-cbz-aminoisonipecotic acid; 1,4-Piperidinedicarboxylic acid, 4-[[(phenylmethoxy)carbonyl]amino]-, 1-(1,1-dimethylethyl) ester; 4-(Cbz-amino)-1-Boc-piperidine-4-carboxylic acid; 4-{[(Benzyloxy)carbonyl]amino}-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid; 4-{[(Benzyloxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid; 1-Boc-4-N-Cbz-aminopiperidine-4-carboxylicacid; 4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid; MFCD02683056; 1-n-boc-4-(n-cbz-amino)piperidine-4-carboxylic acid

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 556.1±50.0 °C at 760 mmHg
• 分子式: C₁₉H₂₆N₂O₆
• 分子量: 378.419
• 闪点: 290.1±30.1 °C
• 精确质量: 378.179077
• PSA: 105.17000
• LogP: 2.77
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.567
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36/37/39
• 海关编码: 2933399090

合成路线

501-53-1 183673-68-9 ~71% 288154-16-5

文献：ILDONG PHARMACEUTICAL CO., LTD. Patent: US2010/168421 A1, 2010 ; Location in patent: Page/Page column 7 ;

321997-89-1 501-53-1 ~% 288154-16-5

文献：LG LIFE SCIENCES LTD.; YAMANOUCHI PHARMACEUTICAL CO., LTD. Patent: WO2005/47253 A1, 2005 ; Location in patent: Page/Page column 49 ; WO 2005/047253 A1

13139-17-8 183673-71-4 ~% 288154-16-5

文献：Davies, David Thomas; Markwell, Roger Edward; Pearson, Neil David Patent: US2004/53928 A1, 2004 ;

501-53-1 183673-71-4 ~76% 288154-16-5

文献：Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451

24424-99-5 ~% 288154-16-5

文献：Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451

41979-39-9 ~% 288154-16-5

文献：Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451

13625-39-3 ~% 288154-16-5

文献：Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451

183673-68-9 ~% 288154-16-5

文献：Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451

上下游产品

上游产品  8
501-53-1 183673-68-9 321997-89-1 13139-17-8
183673-71-4 24424-99-5 41979-39-9 13625-39-3
下游产品  3
288154-17-6 288154-18-7 392331-67-8

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%