54739-19-4

• 常用中文名：氯伏胺
• 常用英文名：Clovoxamine fumarate
• CAS号：54739-19-4
• 分子式：C₁₄H₂₁ClN₂O₂
• 分子量：284.78200
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-02-27 08:00:00
• 更新时间：2024-01-06 16:09:53
• Clovoxamine (DU23811) (Compound 35) 对血清素转运蛋白 (SERT) 具有结合亲和力 (Ki: 61 nM)。Clovoxamine 是一种 5-HT 和去甲肾上腺素再摄取 (NE) 再摄取抑制剂。Clovoxamine 是一种抗抑郁化合物。

名称

• 中文名: 氯伏胺
• 英文名: clovoxamine
• 英文别名: 2-[(E)-[1-(4-chlorophenyl)-5-methoxypentylidene]amino]oxyethanamine; Clovoxamine; Clovoxaminum [INN-Latin]; p-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime; (E)-1-(4-Chlorophenyl)-5-methoxy-1-pentanone O-(2-aminoethyl)oxime; Clovoxamina [Spanish]; 4'-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime; clovoxaminum; 1-Pentanone,1-(4-chlorophenyl)-5-methoxy-,O-(2-aminoethyl)oxime,(E); Clovoxamina [INN-Spanish]

物化性质

• 密度: 1.12g/cm3
• 沸点: 387.8ºC at 760 mmHg
• 分子式: C₁₄H₂₁ClN₂O₂
• 分子量: 284.78200
• 闪点: 188.3ºC
• 精确质量: 284.12900
• PSA: 56.84000
• LogP: 3.53640
• 折射率: 1.519

生物活性

• 描述: Clovoxamine (DU23811) (Compound 35) 对血清素转运蛋白 (SERT) 具有结合亲和力 (Ki: 61 nM)。Clovoxamine 是一种 5-HT 和去甲肾上腺素再摄取 (NE) 再摄取抑制剂。Clovoxamine 是一种抗抑郁化合物。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 参考文献:

  [1]. Staroń J, et al. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. Eur J Med Chem. 2021 Aug 5;220:113533.

  [2]. Saletu B, et al. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49(1-2):63-86.

  [3]. de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SA8148000 CHEMICAL NAME : 1-Pentanone, 1-(4-chlorophenyl)-5-methoxy-, O-(2-aminoethyl)oxime, (E)- CAS REGISTRY NUMBER : 54739-19-4 LAST UPDATED : 199706 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C14-H21-Cl-N2-O2 MOLECULAR WEIGHT : 284.82 WISWESSER LINE NOTATION : Z2ONUYR DG&4O1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1470 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,563,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 681 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,563,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1215 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,563,1979