1063697-17-5

• 常用中文名：2-(三氟甲基)吡啶-3-醇
• 常用英文名：2-(Trifluoromethyl)-3-pyridinol
• CAS号：1063697-17-5
• 分子式：C₆H₄F₃NO
• 分子量：163.097
• 发布时间：2018-09-16 09:00:28
• 更新时间：2024-01-08 14:02:58

名称

• 中文名: 2-(三氟甲基)吡啶-3-醇
• 英文名: 2-(trifluoromethyl)pyridin-3-ol
• 英文别名: trifluoromethylhydroxypyridine; QC-3520; 2-(Trifluoromethyl)pyridin-3-ol; 3-Hydroxy-2-(trifluoromethyl)pyridine; 3-Pyridinol, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)-3-pyridinol; 2-(TRIFLUOROMETHYL)-3-HYDROXYPYRIDINE

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 254.3±35.0 °C at 760 mmHg
• 分子式: C₆H₄F₃NO
• 分子量: 163.097
• 闪点: 107.6±25.9 °C
• 精确质量: 163.024506
• PSA: 33.12000
• LogP: 2.23
• 蒸汽压: 0.0±0.5 mmHg at 25°C
• 折射率: 1.457
• 储存条件: 室温

合成路线

368-48-9 ~70% 1063697-17-5

文献：Ma, Yongmin; Roy, Sourav; Kong, Xiaole; Chen, Yulin; Liu, Dingyong; Hider, Robert C. Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2185 - 2195

40263-57-8 1514-87-0 ~% 1063697-17-5

文献：BOEHRINGER INGELHEIM INTERNATIONAL GmbH; STAMMERS, Timothy; BARBEAU, Xavier; BEAULIEU, Pierre; BERTRAND-LAPERLE, Megan; BROCHU, Christian; EDWARDS, Paul, J.; FORGIONE, Pasquale; GODBOUT, Cedrickx; HUCKE, Oliver; JOLY, Marc-Andre; LANDRY, Serge; LEPAGE, Olivier; NAUD, Julie; PESANT, Marc; POIRIER, Martin; POIRIER, Maude; THAVONEKHAM, Bounkham Patent: WO2011/32277 A1, 2011 ; Location in patent: Page/Page column 46 ; WO 2011/032277 A1

109-00-2 2314-97-8 ~43% 1063697-17-5

文献：Kino, Tatsuhito; Nagase, Yu; Ohtsuka, Yuhki; Yamamoto, Kyoko; Uraguchi, Daisuke; Tokuhisa, Kenji; Yamakawa, Tetsu Journal of Fluorine Chemistry, 2010 , vol. 131, # 1 p. 98 - 105

947533-39-3 ~% 1063697-17-5

文献：Xia, Yan; Chackalamannil, Samuel; Greenlee, William J.; Jayne, Charles; Neustadt, Bernard; Stamford, Andrew; Vaccaro, Henry; Xu, Xiaoying; Baker, Hana; O'Neill, Kim; Woods, Morgan; Hawes, Brian; Kowalski, Tim Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3290 - 3296

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