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6306-71-4

6306-71-4结构式

常用中文名：N-(1H-苯并咪唑-2-基)氨基甲酸乙酯
常用英文名：N-(1H-Benzimidazol-2-yl)carbamic acid ethyl ester
CAS号：6306-71-4
分子式：C₁₀H₁₁N₃O₂
分子量：205.21
相关类别：研究领域感染
发布时间：2018-06-13 11:28:03
更新时间：2024-01-10 08:16:38
洛本唑是一种强效的驱虫药。洛本达唑抑制肠贾第鞭毛虫菌株[1]。

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中文名	N-(1H-苯并咪唑-2-基)氨基甲酸乙酯
英文名	ethyl N-(1H-benzimidazol-2-yl)carbamate
中文别名	洛苯达唑
英文别名	Ethyl 2-benzimidazolecarbamate Lobendazole Ethyl 2-benzimidazolylcarbamate Ethyl 1H-benzimidazol-2-ylcarbamate ethyl benzimidazole-2-carbamate 2-Carboethoxyaminobenzimidazole

描述	洛本唑是一种强效的驱虫药。洛本达唑抑制肠贾第鞭毛虫菌株[1]。
相关类别	研究领域 >> 感染
参考文献	[1]. Jaime Pérez-Villanueva, et al. The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. Eur J Med Chem. 2021 Feb 5;211:113110.

密度	1.358
分子式	C₁₀H₁₁N₃O₂
分子量	205.21
精确质量	205.08500
PSA	67.01000
LogP	2.20430
折射率	1.682
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:2 3.氢键受体数量:3 4.可旋转化学键数量:3 5.互变异构体数量:3 6.拓扑分子极性表面积:67 7.重原子数量:15 8.表面电荷:0 9.复杂度:235 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EY8590000

CHEMICAL NAME :: Carbamic acid, (2-benzimidazolyl)-, ethyl ester

CAS REGISTRY NUMBER :: 6306-71-4

LAST UPDATED :: 199412

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H11-N3-O2

MOLECULAR WEIGHT :: 205.24

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04389 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 82400 ug/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 21,87,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 164 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - physical

REFERENCE :: ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 21,87,1990

海关编码	2933990090

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934-32-7

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%