丙酮酸-13C

丙酮酸-13C用途

丙酮酸-13C是13C标记的丙酮酸[1]。丙酮酸是碳水化合物、蛋白质和脂肪代谢的中间代谢产物[2]。

丙酮酸-13C名称

[ CAS 号 ]:
99124-30-8

[ 中文名 ]:
丙酮酸-13C

[ 英文名 ]:
Pyruvic acid-13C

[英文别名 ]:

2-Oxopropionic acid-1-13C
|A-Ketopropionic acid-1-13C
Pyruvic-1-13C acid (free acid)
Pyruvic acid-1-13C
13C Labeled pyruvic acid
PYRUVIC-1-13C ACID (FREE ACID)

丙酮酸-13C生物活性

[ 描述 ]:

丙酮酸-13C是13C标记的丙酮酸[1]。丙酮酸是碳水化合物、蛋白质和脂肪代谢的中间代谢产物[2]。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Kładna A, et al. Reactivity of pyruvic acid and its derivatives towards reactive oxygen species. Luminescence. 2015 Nov;30(7):1153-8.

丙酮酸-13C物理化学性质

[ 分子式 ]:
C₃H₄O₃

[ 分子量 ]:
89.05470

[ 精确质量 ]:
89.01940

[ PSA ]:
54.37000

丙酮酸-13CMSDS

丙酮酸-13C安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 危险品运输编码 ]:
UN 3265 8 / PGII

丙酮酸-13C合成路线

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丙酮酸-13C文献

Using [1-(13) C]lactic acid for hyperpolarized (13) C MR cardiac studies.

Magn. Reson. Med. , doi:10.1002/mrm.2535, (2014)

Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]...

Enhancing the [13C]bicarbonate signal in cardiac hyperpolarized [1-13C]pyruvate MRS studies by infusion of glucose, insulin and potassium.

NMR Biomed. 26(11) , 1496-500, (2013)

A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, ...

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