4-氨基苯乙酮
4-氨基苯乙酮用途
4-氨基苯乙酮名称
[ CAS 号 ]:
99-92-3
[ 中文名 ]:
4-氨基苯乙酮
[ 英文名 ]:
4-Aminoacetophenone
[中文别名 ]:
[英文别名 ]:
- 1-(4-Aminophenyl)ethanone
- MFCD00007896
- p-Aminoacetylbenzene
- p-Aminoacetophenone
- Ethanone, 1-(4-aminophenyl)-
- p-acetylaniline
- 4-Acetylaniline
- 4-Amino acetophenone
- EINECS 202-801-2
4-氨基苯乙酮生物活性
4-氨基苯乙酮物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
294.8±13.0 °C at 760 mmHg
[ 熔点 ]:
103-107 °C(lit.)
[ 分子式 ]:
C8H9NO
[ 分子量 ]:
135.16
[ 闪点 ]:
132.1±19.8 °C
[ 精确质量 ]:
135.068420
[ PSA ]:
43.09000
[ LogP ]:
0.41
[ 外观性状 ]:
黄色至棕色结晶粉末
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.571
[ 储存条件 ]:
库房通风低温干燥
4-氨基苯乙酮MSDS
4-氨基苯乙酮毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AM5500000
- CHEMICAL NAME :
- Acetophenone, p-amino-
- CAS REGISTRY NUMBER :
- 99-92-3
- BEILSTEIN REFERENCE NO. :
- 0471493
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C8-H9-N-O
- MOLECULAR WEIGHT :
- 135.18
- WISWESSER LINE NOTATION :
- ZR DV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 381 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 14,465,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 260 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 80,31,1944
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 596 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 14,465,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >70 mg/kg
- TOXIC EFFECTS :
- Blood - methemoglobinemia-carboxyhemoglobin
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 80,31,1944
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 133 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
4-氨基苯乙酮安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 警示性声明 ]:
P301 + P312 + P330
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful;
[ 风险声明 (欧洲) ]:
R22
[ 安全声明 (欧洲) ]:
S26-S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
AM5500000
[ 海关编码 ]:
29223900
4-氨基苯乙酮合成路线
4-氨基苯乙酮上下游产品
4-氨基苯乙酮上游产品
4-氨基苯乙酮下游产品
4-氨基苯乙酮制备
(1)由对硝基苯乙酮还原:将氯化亚锡、浓盐酸放入反应罐,冷却,搅拌加入对硝基苯乙酮。自然升温至90℃时,急冷至85℃,继续冷至室温,搅拌1h,过滤,滤饼加过量氢氧化钠溶液分解复合物。过滤,得对氨基苯乙酮粗品,用稀乙醇时得重结晶可得熔点105-106℃的精品。收率61%用铁粉和氯化钠代替氯化亚锡也可进行还原反应。
(2)由乙酰苯胺、乙酐制得乙酰氨基苯乙酮,再水解、中和而得。乙酐、乙酰苯、无水氯化锌混合保持微沸5h,稍冷,倒入浓盐酸,回流水解5h,放置至室温,加入25%氢氧化钠至调节pH为7-8,通入蒸汽赶去苯胺,加脱色炭过滤,减压浓缩,冷却得橙黄色结晶。滤干得粗品。再用水进行重结晶提纯。
(3)将醋酐、乙酰苯胺以1∶ 1( 摩尔比)的比例与催化剂量的无水氯化锌混合均匀,加热回流5h,加入浓盐酸后继续回流水解5h:
反应结束后,静置冷却至室温,加入25%的氢氧化钠溶液至油水明显分层,在分离出的油层中加入水,再用25%的氢氧化钠调节ph值至7~8,然后用水蒸气蒸馏蒸出苯胺。剩余物用活性炭脱色,过滤所得滤液进行减压浓缩,冷却所的橙黄色结晶用水重结晶,以制得纯品对氨基苯乙酮。
4-氨基苯乙酮海关
[ 海关编码 ]: 2922399090
[ 中文概述 ]:
2922399090 其他氨基醛、氨基酮及其盐(包括氨基醌及其盐,但含有一种以上含氧基的除外). 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
4-氨基苯乙酮文献
Biomed. Chromatogr. 29 , 1197-202, (2015)
A simple, rapid and reliable liquid chromatography-electrospray ionization tandem mass spectrometry method was established and validated for the determination of methotrexate in human plasma. After a ...
Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.Pharm. Acta Helv. 73(4) , 215-8, (1998)
The thioureido derivative of 4-aminoacetophenone aryl semicarbazone have been prepared. These derivatives have been characterised on the basis of different physicochemical evidences. The anti-HIV-1 (H...
[Determination of p-aminoacetophenone and changes in its levels in a levorin producer depending on culture conditions].Antibiotiki 26(8) , 566-70, (1981)
A method for spectrophotometric determination of p-aminoacetophenone (p-AAP) in the mycelium and fermentation broth filtrates of organisms producing polyenic macrolide antibiotics is described. The le...
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标题:4-氨基苯乙酮_MSDS_用途_密度_CAS号【99-92-3】_化源网 地址:https://www.chemsrc.com/amp/cas/99-92-3_895210.html