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4-氨基苯乙酮

4-氨基苯乙酮用途

1-(4-氨基苯基)乙酮是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

4-氨基苯乙酮名称

[ CAS 号 ]:
99-92-3

[ 中文名 ]:
4-氨基苯乙酮

[ 英文名 ]:
4-Aminoacetophenone

[中文别名 ]:

[英文别名 ]:

1-(4-Aminophenyl)ethanone
MFCD00007896
p-Aminoacetylbenzene
p-Aminoacetophenone
Ethanone, 1-(4-aminophenyl)-
p-acetylaniline
4-Acetylaniline
4-Amino acetophenone
EINECS 202-801-2

4-氨基苯乙酮生物活性

[ 描述 ]:

1-(4-氨基苯基)乙酮是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

4-氨基苯乙酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
294.8±13.0 °C at 760 mmHg

[ 熔点 ]:
103-107 °C(lit.)

[ 分子式 ]:
C₈H₉NO

[ 分子量 ]:
135.16

[ 闪点 ]:
132.1±19.8 °C

[ 精确质量 ]:
135.068420

[ PSA ]:
43.09000

[ LogP ]:
0.41

[ 外观性状 ]:
黄色至棕色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.571

[ 储存条件 ]:
库房通风低温干燥

4-氨基苯乙酮MSDS

4-氨基苯乙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM5500000

CHEMICAL NAME :: Acetophenone, p-amino-

CAS REGISTRY NUMBER :: 99-92-3

BEILSTEIN REFERENCE NO. :: 0471493

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H9-N-O

MOLECULAR WEIGHT :: 135.18

WISWESSER LINE NOTATION :: ZR DV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 381 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 14,465,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 80,31,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 596 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 14,465,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >70 mg/kg

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 80,31,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

4-氨基苯乙酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AM5500000

[ 海关编码 ]:
29223900

4-氨基苯乙酮合成路线

4-氨基苯乙酮上下游产品

4-氨基苯乙酮上游产品

4-氨基苯乙酮下游产品

4-氨基苯乙酮制备

（1）由对硝基苯乙酮还原：将氯化亚锡、浓盐酸放入反应罐，冷却，搅拌加入对硝基苯乙酮。自然升温至90℃时，急冷至85℃，继续冷至室温，搅拌1h，过滤，滤饼加过量氢氧化钠溶液分解复合物。过滤，得对氨基苯乙酮粗品，用稀乙醇时得重结晶可得熔点105-106℃的精品。收率61%用铁粉和氯化钠代替氯化亚锡也可进行还原反应。

（2）由乙酰苯胺、乙酐制得乙酰氨基苯乙酮，再水解、中和而得。乙酐、乙酰苯、无水氯化锌混合保持微沸5h，稍冷，倒入浓盐酸，回流水解5h，放置至室温，加入25%氢氧化钠至调节pH为7-8，通入蒸汽赶去苯胺，加脱色炭过滤，减压浓缩，冷却得橙黄色结晶。滤干得粗品。再用水进行重结晶提纯。

（3）将醋酐、乙酰苯胺以1∶ 1（摩尔比）的比例与催化剂量的无水氯化锌混合均匀，加热回流5h，加入浓盐酸后继续回流水解5h：

反应结束后，静置冷却至室温，加入25%的氢氧化钠溶液至油水明显分层，在分离出的油层中加入水，再用25%的氢氧化钠调节ph值至7～8，然后用水蒸气蒸馏蒸出苯胺。剩余物用活性炭脱色，过滤所得滤液进行减压浓缩，冷却所的橙黄色结晶用水重结晶，以制得纯品对氨基苯乙酮。

4-氨基苯乙酮海关

[ 海关编码 ]: 2922399090

[ 中文概述 ]:
2922399090 其他氨基醛、氨基酮及其盐（包括氨基醌及其盐，但含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

4-氨基苯乙酮文献

A simple, rapid and reliable liquid chromatography-mass spectrometry method for determination of methotrexate in human plasma and its application to therapeutic drug monitoring.

Biomed. Chromatogr. 29 , 1197-202, (2015)

A simple, rapid and reliable liquid chromatography-electrospray ionization tandem mass spectrometry method was established and validated for the determination of methotrexate in human plasma. After a ...

Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.

Pharm. Acta Helv. 73(4) , 215-8, (1998)

The thioureido derivative of 4-aminoacetophenone aryl semicarbazone have been prepared. These derivatives have been characterised on the basis of different physicochemical evidences. The anti-HIV-1 (H...

[Determination of p-aminoacetophenone and changes in its levels in a levorin producer depending on culture conditions].

Antibiotiki 26(8) , 566-70, (1981)

A method for spectrophotometric determination of p-aminoacetophenone (p-AAP) in the mycelium and fermentation broth filtrates of organisms producing polyenic macrolide antibiotics is described. The le...

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