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2,6-二羟基异烟酸

2,6-二羟基异烟酸用途

柠檬酸是一种弱荧光化合物,其光学性质取决于聚集态和化学环境。柠檬酸在高浓度下极易形成二聚体[1]。

2,6-二羟基异烟酸名称

[ CAS 号 ]:
99-11-6

[ 中文名 ]:
柠嗪酸

[ 英文名 ]:
Citrazinic acid

[中文别名 ]:

[英文别名 ]:

2,6-二羟基异烟酸生物活性

[ 描述 ]:

柠檬酸是一种弱荧光化合物,其光学性质取决于聚集态和化学环境。柠檬酸在高浓度下极易形成二聚体[1]。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Stagi L, et al. Anomalous Optical Properties of Citrazinic Acid under Extreme pH Conditions. ACS Omega. 2020 May 5;5(19):10958-10964.  

2,6-二羟基异烟酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
630.3±55.0 °C at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C6H5NO4

[ 分子量 ]:
155.11

[ 闪点 ]:
335.0±31.5 °C

[ 精确质量 ]:
155.021851

[ PSA ]:
90.65000

[ LogP ]:
-1.50

[ 外观性状 ]:
米色略棕色粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.686

[ 储存条件 ]:
室温

[ 水溶解性 ]:
practically insoluble

2,6-二羟基异烟酸MSDS

2,6-二羟基异烟酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NS1400000
CHEMICAL NAME :
Isonicotinic acid, 2,6-dihydroxy-
CAS REGISTRY NUMBER :
99-11-6
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C6-H5-N-O4
MOLECULAR WEIGHT :
155.12
WISWESSER LINE NOTATION :
T6NJ BQ DVQ FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1498 No. of Facilities: 43 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 255 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1498 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 1 No. of Employees: 34 (estimated) No. of Female Employees: 3 (estimated)

2,6-二羟基异烟酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S36/37/39-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
NS1400000

[ 海关编码 ]:
29333999

2,6-二羟基异烟酸合成路线

2,6-二羟基异烟酸上下游产品

2,6-二羟基异烟酸制备

由柠檬酸经酯化、氨解、闭环而得。酯化反应在硫酸存在下进行,经48h脱水后,回收溶剂和乙醇,残留物经水洗、碱洗、水洗至pH为6,得柠檬酸三乙酯粗品。加入氨水,通氨至饱和。放置以后,再通氨饱和,每天饱和一次,共三次,滤出结晶,将所得柠檬酸三甲酸胺于硫酸存在下120℃左右保温3h,慢慢倒入蒸馏水中,得粗品,再用酸碱精制而得柠嗪酸。采用柠檬酸三甲酯的制备方法大致与上述过程相同。在柠檬酸三甲酯中加入氨水,于室温放置约48h,浓缩后,加75%硫酸,放置12h,于130℃加热10min,用水稀释,过滤沉淀物即得粗品。将粗品溶于氨水,加盐酸即得沉淀,过滤,水洗,干燥。收率为69%。

2,6-二羟基异烟酸海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2,6-二羟基异烟酸文献

6,6'-Dibromo-4,4'-di(hexoxymethyl)-2,2'- bipyridine: a new solubilizing building block for macromolecular and supramolecular applications.

J. Org. Chem. 71(12) , 4696-9, (2006)

Although brominated bipyridines and terpyridines are highly desirable synthetic building blocks for both ligand design and macro- or supramolecular applications, few such synthetic precursors have bee...

Synthesis and antimicrobial activity of some new pyrimidinone and oxazinone derivatives fused with thiophene rings using 2-chloro-6-ethoxy-4-acetylpyridine as starting material.

Molecules 17(11) , 13642-55, (2012)

A series of pyridines, pyrimidinones, oxazinones and their derivatives were synthesized as antimicrobial agents using citrazinic acid (2,6-dihydroxyisonicotinic acid) as a starting material. α,β-Unsat...


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相关化工产品/化学物质:

推荐生产厂家/供应商:

公司名:上海吉至生化科技有限公司

区域:上海市奉贤区

价格:
¥218.0/25g ¥608.0/100g ¥2678.0/500g

联系人:刘佳

产品详情:柠嗪酸


公司名:上海阿拉丁生化科技股份有限公司

区域:上海市浦东新区

价格:
¥507.9/100g ¥161.9/25g ¥2059.9/500g ¥需询单/1g

联系人:阿拉丁

产品详情:柠嗪酸


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