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间硝基三氟甲苯

间硝基三氟甲苯用途

用作医药、农药、染料中间体。

间硝基三氟甲苯名称

[ CAS 号 ]:
98-46-4

[ 中文名 ]:
间硝基三氟甲苯

[ 英文名 ]:
3-Nitrobenzotrifluoride

[中文别名 ]:

[英文别名 ]:

USAF ma-5
Toluene, α,α,α-trifluoro-m-nitro-
Benzene, 1-nitro-3-(trifluoromethyl)-
EINECS 202-670-1
MFCD00007260
3-Nitrobenzotrifluor
nitrobenzotrifluoride
3-Nitrobenzotrifluoride
m-Nitrobenzotrifluoride
3-trifluoromethyl-1-nitrobenzene

间硝基三氟甲苯物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
202.8±0.0 °C at 760 mmHg

[ 熔点 ]:
-5 °C

[ 分子式 ]:
C₇H₄F₃NO₂

[ 分子量 ]:
191.107

[ 闪点 ]:
87.8±0.0 °C

[ 精确质量 ]:
191.019409

[ PSA ]:
45.82000

[ LogP ]:
2.62

[ 外观性状 ]:
透明黄色液体

[ 蒸汽压 ]:
0.4±0.3 mmHg at 25°C

[ 折射率 ]:
1.473

[ 储存条件 ]:
库房通风低温干燥,与氧化剂,食品分开储运

[ 水溶解性 ]:
0.4 g/L (20 ºC)

间硝基三氟甲苯MSDS

间硝基三氟甲苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT3500000

CHEMICAL NAME :: Toluene, 3-nitro-alpha,alpha,alpha-trifluoro-

CAS REGISTRY NUMBER :: 98-46-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C7-H4-F3-N-O2

MOLECULAR WEIGHT :: 191.12

WISWESSER LINE NOTATION :: WNR CXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 610 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 10,131,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,92,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 10,131,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 880 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,92,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 573 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 130,250,1928 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

间硝基三氟甲苯安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H319-H330-H335

[ 警示性声明 ]:
P260-P284-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R21/22;R26;R36/37/38;R52/53

[ 安全声明 (欧洲) ]:
S26-S28-S36/37-S45-S61-S36/37/39-S28A

[ 危险品运输编码 ]:
UN 2306 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
XT3500000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2904909090

间硝基三氟甲苯合成路线

间硝基三氟甲苯上下游产品

间硝基三氟甲苯上游产品

间硝基三氟甲苯下游产品

间硝基三氟甲苯制备

1、由三氟甲苯经硝化而得。将浓硫酸加入反应锅内，在搅拌冷却下加入发烟硫酸及浓硝酸，加热至40℃，滴加三氯甲苯，控制温度40-45℃。加毕，在50-55℃反应3h，冷至室温，静置分去下层酸液。上层液放入5倍量冰水中，静置分层，分出的硝基物用2%碳酸钠溶液及水洗涤，即得间硝基三氟甲苯。收率接近93%。

2、其制备方法是在反应瓶中加入浓硫酸、浓硝酸，开动搅拌，滴加三氟甲苯，控制反应温度在50℃左右，滴加完后再继续搅拌反应2 h，然后静置分层，分出废酸，有机相依次用水、碱和水洗涤至pH=7～8，粗产品中约含间位体91%、邻位体6.8％、对位体2.0％，将粗产物进行分馏得3-三氟甲基硝基苯。

间硝基三氟甲苯海关

[ 海关编码 ]: 2904909090

[ 中文概述 ]:
2904909090 其他烃的磺化、硝化、亚硝化衍生物（不论是否卤化）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

间硝基三氟甲苯文献

The Structures of Biphenyl, o-Terphenyl and Tetraphenylene1. Karle IL and Brockway LO.

J. Am. Chem. Soc. 66(11) , 1974-1979, (1944)

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