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阿西太松

阿西太松用途

缩醛(Stovarsol)是一种强效口服活性抗感染剂。乙醛具有抗寄生虫活性。乙醛具有研究直肠炎的潜力[1]。

阿西太松名称

[ CAS 号 ]:
97-44-9

[ 中文名 ]:
对甲苯磺酰乙腈

[ 英文名 ]:
ACETARSONE

[中文别名 ]:

乙酰氨基羟基苯胂酸

[英文别名 ]:

svc
Amassn
Oracid
amoebal
190f
MFCD00019936
amarsan
goyl
f190
Arsonic acid

阿西太松生物活性

[ 描述 ]:

缩醛(Stovarsol)是一种强效口服活性抗感染剂。乙醛具有抗寄生虫活性。乙醛具有研究直肠炎的潜力[1]。

[ 相关类别 ]:

研究领域 >> 感染

[体内研究]

乙醛(20 mg/kg；口服每天一次,持续 4.天) 在猪的毛囊炎中表现出抗感染活性[1]。动物模型：2个月大的感染大肠杆菌的仔猪[1]剂量：20 mg/kg给药：口服。；每天一次,持续4天结果：65%的仔猪临床上已经康复,在治疗结束时,没有观察到任何动物腹泻。

[参考文献]

[1]. Argyriou K, et al. Acetarsol in the management of mesalazine-refractory ulcerative proctitis: a tertiary-level care experience. Eur J Gastroenterol Hepatol. 2019 Feb;31(2):183-186.

[2]. V.S. Pandey, et al. Successful therapy of balantidiosis of pigs with acetarsol and oxytetracycline. Veterinary parasitology. 1977, 3(2):189-193.

阿西太松物理化学性质

[ 沸点 ]:
72.17°C

[ 熔点 ]:
220.5°C

[ 分子式 ]:
C₈H₁₀AsNO₅

[ 分子量 ]:
275.09000

[ 精确质量 ]:
274.97700

[ PSA ]:
106.86000

[ 外观性状 ]:
solid

[ 储存条件 ]:
库房通风低温干燥

阿西太松MSDS

阿西太松毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CF8400000

CHEMICAL NAME :: m-Arsanilic acid, N-acetyl-4-hydroxy-

CAS REGISTRY NUMBER :: 97-44-9

BEILSTEIN REFERENCE NO. :: 2941984

LAST UPDATED :: 199703

DATA ITEMS CITED :: 34

MOLECULAR FORMULA :: C8-H10-As-N-O5

MOLECULAR WEIGHT :: 275.11

WISWESSER LINE NOTATION :: Q-AS-QO&R DQ CMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 86 mg/kg/8D

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 89 mg/kg/9D

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Endocrine - other changes Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 155 mg/kg/2D-I

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1576 mg/kg/2D-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - urine volume decreased

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 20 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 mg(As)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,16,1971 OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993 OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993 OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993 OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

阿西太松安全信息

[ 危害码 (欧洲) ]:
T: Toxic;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R23/25

[ 安全声明 (欧洲) ]:
S28;S45;S60;S61

[ 危险品运输编码 ]:
UN 3465 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
CF8400000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2931900090

阿西太松合成路线

阿西太松上下游产品

阿西太松上游产品

阿西太松下游产品

阿西太松制备

1.3-氨基-4-羟基苯胂酸乙酰化而得。将3-氨基-4-羟基苯胂酸加入5%氢氧化钠溶液中，搅拌使全溶。调节pH至8，加热至30-35℃，在剧烈搅拌下加入乙酐，析出沉淀，继续搅拌1h，于55-60℃加入盐酸，析出结晶，过滤，水洗，得粗品乙酰胂胺。精制：将粗品溶于5%氢氧化钠溶液中，加活性炭，搅拌，过滤，在滤液中缓缓加入10%硫酸，使刚果红试纸呈蓝色，析出结晶。过滤，洗涤，得精制的乙酰胂胺。

阿西太松海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%