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双氯酚

双氯酚用途

Dichlorophen是一驱绦虫化合物。

双氯酚名称

[ CAS 号 ]:
97-23-4

[ 中文名 ]:
双氯酚

[ 英文名 ]:
Dichlorophen

[中文别名 ]:

[英文别名 ]:

2,2'-Dihydroxy-5,5'-dichlorodiphenylmethane
Gefir
DDM
2,2'-Methylenebis(4-chlorophenol)
Dichlorofen
Bis[5-chloro-2-hydroxyphenyl]methane
Halenol
Preventol G-D
Di[5-chloro-2-hydroxyphenyl]methane
Phenol, 2,2'-methylenebis[4-chloro-

双氯酚生物活性

[ 描述 ]:

Dichlorophen是一驱绦虫化合物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[相关活性小分子]

双氯酚物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
418.7±40.0 °C at 760 mmHg

[ 熔点 ]:
168-172 °C(lit.)

[ 分子式 ]:
C₁₃H₁₀Cl₂O₂

[ 分子量 ]:
269.123

[ 闪点 ]:
207.0±27.3 °C

[ 精确质量 ]:
268.005798

[ PSA ]:
40.46000

[ LogP ]:
4.62

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.650

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with strong bases, strong oxidizing agents.

[ 水溶解性 ]:
<0.1 g/100 mL at 22 ºC

双氯酚MSDS

双氯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM0175000

CHEMICAL NAME :: Phenol, 2,2'-methylenebis(4-chloro-

CAS REGISTRY NUMBER :: 97-23-4

BEILSTEIN REFERENCE NO. :: 1884514

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C13-H10-Cl2-O2

MOLECULAR WEIGHT :: 269.13

WISWESSER LINE NOTATION :: QR DG B1R BQ EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1506 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 150 ug/plate

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 19(Suppl 21),2,1992 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84582 No. of Facilities: 855 (estimated) No. of Industries: 7 No. of Occupations: 7 No. of Employees: 3398 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84582 No. of Facilities: 441 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 4290 (estimated) No. of Female Employees: 2030 (estimated)

双氯酚安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319-H400

[ 警示性声明 ]:
P273-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R36;R50/53

[ 安全声明 (欧洲) ]:
S26-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SM0175000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2908199022

双氯酚合成路线

双氯酚上下游产品

双氯酚上游产品

双氯酚下游产品

双氯酚制备

1、由对氯苯酚与甲醛反应而得。缩后反应在溶剂甲醇（或乙醇）中进行，以硫酸为催化剂，反应温度控制在-5℃以下。另一种工艺方法是以分子筛作催化剂，在这种情况下，对氯苯酚与甲醛的缩合反应在110℃进行。

2、首先将溶剂乙醇和催化剂量的浓硫酸加入反应釜，再加入277kg对氯酚中，冷却至-10～0℃，开始滴加30kg甲醛，反应6h。反应结束后静置，过滤，干燥，得固体产品。

3.由对氯苯酚与甲醛缩合反应，一种方法是在溶剂甲醇（或乙醇）中进行，以硫酸为催化剂得到。也可以以分子筛作催化剂，反应在温度110℃进行。

4.由对氯苯酚与甲醛缩合反应，以硫酸为催化剂，在溶剂甲醇（或乙醇）中进行，反应温度控制在-5℃以下；或者以分子筛作催化剂，反应在温度110℃进行亦可。

双氯酚海关

[ 海关编码 ]: 2908199022

[ 中文概述 ]:
2908199022 双氯酚。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:0.0%。最低关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2908199022 2,2'-methylenebis(4-chlorophenol)。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:5.5%。general tariff:30.0%

双氯酚文献

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.

Regul Toxicol Pharmacol 72 , 578-85, (2015)

Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic in...

Rational design of indoleamine 2,3-dioxygenase inhibitors.

J. Med. Chem. 53 , 1172-89, (2010)

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Identification of estrogenic compounds in fish bile using bioassay-directed fractionation.

Environ. Sci. Technol. 38(23) , 6415-23, (2004)

Conjugates of estrogenic chemicals, endogenous as well as xenobiotic, are mainly excreted via bile into the intestine. Therefore, measurement of estrogenic activity in bile yields useful information a...

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双氯酚