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5-(N-甲基-N-异戊基)阿米洛利

5-(N-甲基-N-异戊基)阿米洛利名称

[ CAS 号 ]:
96861-65-3

[ 中文名 ]:
5-(N-甲基-N-异戊基)阿米洛利

[ 英文名 ]:
5-(N-Methyl-N-isobutyl)-Amiloride

[英文别名 ]:

5-(N-Methyl-N-isobutyl)amiloride
Methylisobutylamiloride
MFCD00078567
Lopac-A-5585
5-Nmnia

5-(N-甲基-N-异戊基)阿米洛利物理化学性质

[ 密度 ]:
1.49g/cm3

[ 沸点 ]:
543.9ºC at 760mmHg

[ 熔点 ]:
200-201 °C

[ 分子式 ]:
C₁₁H₁₈ClN₇O

[ 分子量 ]:
299.76000

[ 闪点 ]:
282.8ºC

[ 精确质量 ]:
299.12600

[ PSA ]:
134.01000

[ LogP ]:
2.34230

[ 折射率 ]:
1.664

[ 储存条件 ]:
2-8°C，密封，干燥

5-(N-甲基-N-异戊基)阿米洛利MSDS

详细MSDS(安全技术说明书)

5-(N-甲基-N-异戊基)阿米洛利安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN 2811

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

5-(N-甲基-N-异戊基)阿米洛利文献

Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer.

Int. J. Oncol. 46(4) , 1788-800, (2015)

We have generated a novel monoclonal antibody (mAb), OCAb9-1, which specifically binds to various types of cancer cell lines, but not to normal cells. According to the results of immunoaffinity chroma...

Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer.

Cancer Biol. Ther. 16(3) , 438-49, (2015)

Tumors often contain hypoxic regions resistant to chemo- and radiotherapy. TH-302 (T) is an investigational hypoxia-activated prodrug that selectively releases the DNA cross-linker bromo-isophosphoram...

Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation.

Nat. Commun. 6 , 6426, (2015)

Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic tumour models to cytotoxic therapies is si...

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