去乙基胺碘酮盐酸盐

去乙基胺碘酮盐酸盐用途

Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) 是 Amiodarone 的主要活性代谢产物。Desethylamiodarone hydrochloride 是由 CYP3A 同工酶形成的。Amiodarone 是一种抗心律失常药,用于抑制 ATP 敏感性钾通道,IC50 为 19.1 μM。

去乙基胺碘酮盐酸盐名称

[ CAS 号 ]:
96027-74-6

[ 中文名 ]:
去乙基胺碘酮盐酸盐

[ 英文名 ]:
Desethyl Amiodarone Hydrochloride

[英文别名 ]:

Desethylamiodarone hydrochloride
desethylamiodarone
mono-N-desethylamiodarone hydrochloride
Desethyl Amiodarone Hydrochloride
Amiodarone Impurity 2

去乙基胺碘酮盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 自噬 >> 自噬

信号通路 >> 跨膜转运 >> 钾通道

[参考文献]

[1]. Shayeganpour A, et al. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug Metab Dispos. 2006 Jan;34(1):43-50.

[2]. Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67.

[3]. Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44.

去乙基胺碘酮盐酸盐物理化学性质

[ 沸点 ]:
630.3ºC at 760 mmHg

[ 熔点 ]:
176-178ºC

[ 分子式 ]:
C₂₃H₂₆ClI₂NO₃

[ 分子量 ]:
653.719

[ 闪点 ]:
335ºC

[ 精确质量 ]:
652.969055

[ PSA ]:
51.47000

[ LogP ]:
7.39680

[ 储存条件 ]:
-20°C Freezer, Under Inert Atmosphere

[ 稳定性 ]:
Moisture Sensitive

去乙基胺碘酮盐酸盐MSDS

去乙基胺碘酮盐酸盐安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
7-16-36/37-45

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

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去乙基胺碘酮盐酸盐文献

Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging.

Anal. Chem. 87 , 6696-702, (2015)

Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion mass spectrometry (SIMS) imaging was use...

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