2-氨基-1-丁醇

2-氨基-1-丁醇用途

【用途一】
用于制备乳化剂、表面活性剂和硫化促进剂，有机合成、酸性气体吸收剂。经拆分得（+）2-氨基丁醇，用于生产抗结核药乙胺丁醇。
【用途二】
用作制备乳化剂、表面活性剂、树脂化剂、擦光蜡、硫化促进剂、医药的原料；酸性气体吸收剂，用于脱除硫化氢、二氢化碳。医药用其d-体生产抗结核药乙胺丁醇；本品的d-体还可用作抗菌剂、子宫收止血剂的原料。本产品的衍生物广泛用作各种试剂，反应助剂。

2-氨基-1-丁醇名称

[ CAS 号 ]:
96-20-8

[ 中文名 ]:
(±)-2-氨基-1-丁醇

[ 英文名 ]:
2-Amino-1-butanol

[中文别名 ]:

[英文别名 ]:

2-Aminobutanol
2-aminobutan-1-ol
2-Amino-1-butanol
MFCD00008095
EINECS 202-488-2
1-Butanol, 2-amino-

2-氨基-1-丁醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
177.2±13.0 °C at 760 mmHg

[ 熔点 ]:
-2ºC

[ 分子式 ]:
C₄H₁₁NO

[ 分子量 ]:
89.136

[ 闪点 ]:
82.2±0.0 °C

[ 精确质量 ]:
89.084061

[ PSA ]:
46.25000

[ LogP ]:
-0.43

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.3±0.7 mmHg at 25°C

[ 折射率 ]:
1.446

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
水溶性：完全混溶；可溶于：醇

2-氨基-1-丁醇MSDS

2-氨基-1-丁醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK9625000

CHEMICAL NAME :: 1-Butanol, 2-amino-

CAS REGISTRY NUMBER :: 96-20-8

BEILSTEIN REFERENCE NO. :: 1098274

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H11-N-O

MOLECULAR WEIGHT :: 89.16

WISWESSER LINE NOTATION :: ZY2&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Behavioral - tetany

REFERENCE :: 20PKA3 "Novye Dannye Po Toksikologii Redkikh Metalov Ikh Soedinenii," New Data on the Toxicology of Rare Metals and Their Compounds, Izrael'son, Z.I., ed., Moscow, Izdatel'stvo "Meditsina," 1967 Volume(issue)/page/year: -,-,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 5,338,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00036

2-氨基-1-丁醇安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H400

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8

[ WGK德国 ]:
2

[ RTECS号 ]:
EK9625000

[ 包装等级 ]:
III

[ 危险类别 ]:
8.0

2-氨基-1-丁醇合成路线

2-氨基-1-丁醇上下游产品

2-氨基-1-丁醇上游产品

2-氨基-1-丁醇下游产品

2-氨基-1-丁醇制备

1.由丁烯-1与乙腈、氯气发生氯化加成反应，再经水解、醇化、碱化而得。除碱化操作外，过程在管道化装置中连续按下述顺序进行。丁烯-1的纯度为50-80%。氯化反应摩尔比为丁烯-1：氯：乙腈=1：0.85：7-8反应温度40-50℃，进料流速为2.5-3.0kg/h。氯化反应毕，将反应中的乙腈和二氯丁烷利用乙腈回收塔蒸馏回收。然后进行醇解反应，将馏出的反应液加入相当于丁烯-1重量的盐酸和乙醇中，以常压进料，塔底温度104℃，塔顶温度72-75℃，边反应边蒸出生成的乙酸乙酯、水和乙醇的混合液。醇解反应液，再经氢氧化钠碱化，蒸馏得粗品2-氨基丁醇。最后经减压分馏得含量95%以上的产品。

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