2,5-二甲基苯酚

2,5-二甲基苯酚用途

【用途一】
用作有机合成中间体，用于染料和降血脂药吉非罗齐的合成
【用途二】
有机合成中间体。用于染料和降血脂药吉非罗齐（gemfibroxil）的合成。
【用途三】
有机合成中间体。用作消毒剂、溶剂、药物、增塑剂和润湿剂。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。

2,5-二甲基苯酚名称

[ CAS 号 ]:
95-87-4

[ 中文名 ]:
2-羟基-对二甲苯

[ 英文名 ]:
2,5-Dimethylphenol

[中文别名 ]:

[英文别名 ]:

2,5-Dimethyl-Phenol
2, 5-Dimethylphenol
EINECS 202-461-5
2,5-dimethyl-phenethylamin
2,5-DIMETHYL PHENOL OR 2,5-XYLENOL
2,5-DIMETHYL PHENOL
2,5-Dimethyl-phenaethylamin
2,5-DIMETHYLPHENOL FOR SYNTHESIS
2,5-dimethyl-phenethylamine
Phenol, 2,5-dimethyl-

2,5-二甲基苯酚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
211.1±0.0 °C at 760 mmHg

[ 熔点 ]:
75-77 °C

[ 分子式 ]:
C₈H₁₀O

[ 分子量 ]:
122.164

[ 闪点 ]:
86.7±7.2 °C

[ 精确质量 ]:
122.073166

[ PSA ]:
20.23000

[ LogP ]:
2.40

[ 外观性状 ]:
白色至奶油色结晶粉末

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.540

[ 储存条件 ]:
库房通风低温干燥,与氧化剂,食品原料分开存放

[ 水溶解性 ]:
1 g/100 mL (60 ºC)

2,5-二甲基苯酚MSDS

2,5-二甲基苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE5775000

CHEMICAL NAME :: 2,5-Xylenol

CAS REGISTRY NUMBER :: 95-87-4

BEILSTEIN REFERENCE NO. :: 1099260

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C8-H10-O

MOLECULAR WEIGHT :: 122.18

WISWESSER LINE NOTATION :: QR B1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 444 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972- Volume(issue)/page/year: 8,145,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 730 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 53,227,1935

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 383 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(7-9),329,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 938 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(7-9),329,1968 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4000 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 19,413,1959

2,5-二甲基苯酚安全信息

[ 符号 ]:

GHS05, GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H314-H411

[ 警示性声明 ]:
P273-P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R24/25;R34;R51/53

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S61

[ 危险品运输编码 ]:
UN 2261 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
ZE5775000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2907199090

2,5-二甲基苯酚合成路线

2,5-二甲基苯酚上下游产品

2,5-二甲基苯酚上游产品

2,5-二甲基苯酚下游产品

2,5-二甲基苯酚制备

1. 以2,5-二甲苯胺为原料，经重氮化、水解制得。

2. 烟草：OR，26。

2,5-二甲基苯酚海关

[ 海关编码 ]: 2907199090

[ 中文概述 ]:
2907199090 其他一元酚. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

2,5-二甲基苯酚文献

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Discovery of novel SERCA inhibitors by virtual screening of a large compound library.

Eur. J. Med. Chem. 46 , 1512-23, (2011)

Two screening protocols based on recursive partitioning and computational ligand docking methodologies, respectively, were employed for virtual screens of a compound library with 345,000 entries for n...

Effect of p-xylene metabolites, p-methylbenzyl alcohol and 2,5-dimethylphenol, on rat hepatic and pulmonary microsomal metabolism.

Res. Commun. Chem. Pathol. Pharmacol. 76(1) , 117-20, (1992)

Pulmonary metabolites of p-xylene, p-methylbenzyl alcohol (PMBA) and 2,5-dimethylphenol (DMP), were employed to investigate the divergent effects of p-xylene on pulmonary and hepatic metabolism. Rats ...

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