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硫辛酰胺

硫辛酰胺用途

Lipoamide是丙酮酸脱酰氧化过程中的一个传递乙酰基和氢的辅酶, 用于制药品.

硫辛酰胺名称

[ CAS 号 ]:
940-69-2

[ 中文名 ]:
(+/-)-alpha-硫辛酰胺

[ 英文名 ]:
Lipoamide

[中文别名 ]:

[英文别名 ]:

lipoicin
dl-thioctic acid amide
thioami
5-(1,2-Dithiolan-3-yl)pentanamide
EINECS 213-375-2
vitaminn
MFCD00005475
thioctic amide
lipozyme
lypoaran

硫辛酰胺生物活性

[ 描述 ]:

Lipoamide是丙酮酸脱酰氧化过程中的一个传递乙酰基和氢的辅酶, 用于制药品.

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

硫辛酰胺物理化学性质

[ 密度 ]:
1.169 g/cm3

[ 沸点 ]:
399.2ºC at 760 mmHg

[ 熔点 ]:
127-129ºC(lit.)

[ 分子式 ]:
C₈H₁₅NOS₂

[ 分子量 ]:
205.34100

[ 闪点 ]:
195.2ºC

[ 精确质量 ]:
205.06000

[ PSA ]:
93.69000

[ LogP ]:
2.88610

[ 折射率 ]:
1.562

[ 储存条件 ]:
2-8°C

硫辛酰胺MSDS

硫辛酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JP1185000

CHEMICAL NAME :: 1,2-Dithiolane-3-valeramide

CAS REGISTRY NUMBER :: 940-69-2

BEILSTEIN REFERENCE NO. :: 0122470

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H15-N-O-S2

MOLECULAR WEIGHT :: 205.36

WISWESSER LINE NOTATION :: T5SSTJ C4VZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1980 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

硫辛酰胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
JP1185000

[ 海关编码 ]:
2934999090

硫辛酰胺合成路线

硫辛酰胺上下游产品

硫辛酰胺上游产品

硫辛酰胺下游产品

硫辛酰胺海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

硫辛酰胺文献

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.

Cell 159(7) , 1615-25, (2014)

Sirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no deacetylase activity,...

Molecular characterization of the thioredoxin system from Methanosarcina acetivorans.

FEBS J. 281(20) , 4598-611, (2014)

The thioredoxin system, composed of thioredoxin reductase (TrxR) and thioredoxin (Trx), is widely distributed in nature, where it serves key roles in electron transfer and in the defense against oxida...

Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level.

Biochemistry 42(7) , 2218-28, (2003)

Lipoamide dehydrogenase catalyzes the reversible NAD(+)-dependent oxidation of the dihydrolipoyl cofactors that are covalently attached to the acyltransferase components of the pyruvate dehydrogenase,...

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